TRS120 Trs120p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TRS120
Official Full Name: Trs120p
Primary source: SGD:S000002815
Locus tag: YDR407C
See related: AllianceGenome:SGD:S000002815; FungiDB:YDR407C; VEuPathDB:YDR407C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to guanyl-nucleotide exchange factor activity. Involved in early endosome to Golgi transport and intra-Golgi vesicle-mediated transport. Located in early endosome and trans-Golgi network. Part of TRAPPII protein complex. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 13. Orthologous to human TRAPPC9 (trafficking protein particle complex subunit 9). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TRS120 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1284069..1287938, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trs120p is required for vesicle traffic from the early endosome to the late Golgi.
Title: Mutants in trs120 disrupt traffic from the early endosome to the late Golgi.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to guanyl-nucleotide exchange factor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in early endosome to Golgi transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intra-Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of TRAPPII protein complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Trs120p

NP_010695.1

Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1284069..1287938 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180715.1 → NP_010695.1 TPA: Trs120p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010695.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VT39, Q04183, Q05731

UniProtKB/TrEMBL

C8Z5X1, N1P8U7

Conserved Domains (1) summary

pfam08626
Location:9 → 1253

TRAPPC9-Trs120; Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit