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    SRP102 Signal recognition particle receptor subunit beta [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SRP102
    Official Full Name
    Signal recognition particle receptor subunit beta
    Primary source
    SGD:S000001637
    Locus tag
    YKL154W
    See related
    AllianceGenome:SGD:S000001637; FungiDB:YKL154W; VEuPathDB:YKL154W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables signal recognition particle binding activity. Involved in protein targeting to ER. Located in endoplasmic reticulum membrane. Part of signal recognition particle receptor complex. Orthologous to human SRPRB (SRP receptor subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SRP102 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (161601..162335)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S27A Neighboring gene tRNA methyltransferase RSM22 Neighboring gene tRNA-Arg Neighboring gene phosphoglycerate mutase GPM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for the function of the beta subunit of the eukaryotic signal recognition particle receptor. Schwartz T, et al. Cell, 2003 Mar 21. PMID 12654246
    2. Homodimerization of the G protein SRbeta in the nucleotide-free state involves proline cis/trans isomerization in the switch II region. Schwartz TU, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16627619, Free PMC Article
    3. The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane. Miller JD, et al. J Cell Biol, 1995 Feb. PMID 7844142, Free PMC Article
    4. A functional GTPase domain, but not its transmembrane domain, is required for function of the SRP receptor beta-subunit. Ogg SC, et al. J Cell Biol, 1998 Jul 27. PMID 9679135, Free PMC Article
    5. Mass-murder deletion of 19 ORFs from Saccharomyces cerevisiae chromosome XI. Vandenbol M, et al. Gene, 2000 Apr 18. PMID 10773443

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results describe the 2.2-A crystal structure of the nucleotide-free signal-recognition particle receptor beta domain.
      Title: Homodimerization of the G protein SRbeta in the nucleotide-free state involves proline cis/trans isomerization in the switch II region.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signal recognition particle binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to ER IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal recognition particle receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle receptor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Signal recognition particle receptor subunit beta
    NP_012768.1
    • Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      161601..162335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179720.1 → NP_012768.1  TPA: Signal recognition particle receptor subunit beta [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012768.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX44, P36057
      UniProtKB/TrEMBL
      A6ZZG9, B3LQU8, C7GT79, C8ZC21, G2WHN6, N1NZN9
      Conserved Domains (1) summary
      pfam09439
      Location:36 → 221
      SRPRB; Signal recognition particle receptor beta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36057.1

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