DNM1 dynamin-related GTPase DNM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DNM1
Official Full Name: dynamin-related GTPase DNM1
Primary source: SGD:S000003924
Locus tag: YLL001W
See related: AllianceGenome:SGD:S000003924; FungiDB:YLL001W; VEuPathDB:YLL001W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: DRP1
Summary: Enables GTPase activity and identical protein binding activity. Involved in several processes, including heme transport; mitochondrion inheritance; and organelle fission. Acts upstream of or within intracellular distribution of mitochondria and membrane bending. Located in cytosol; mitochondrial outer membrane; and peroxisome. Is active in mitochondrion. Used to study encephalopathy due to defective mitochondrial and peroxisomal fission 1. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Orthologous to human DNM1L (dynamin 1 like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DNM1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (147890..150163)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mimicking human Drp1 disease-causing mutations in yeast Dnm1 reveals altered mitochondrial dynamics.
Title: Mimicking human Drp1 disease-causing mutations in yeast Dnm1 reveals altered mitochondrial dynamics.
Molecular Basis of Mitochondrial and Peroxisomal Division Machineries.
Title: Molecular Basis of Mitochondrial and Peroxisomal Division Machineries.
A double deletion mutant in which two essential components of the fission and fusion machinery, Dnm1 and Mgm1, are simultaneously ablated are characterized by impaired respiration and a decrease in mitophagy and replicative lifespan
Title: Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan.
data are consistent with a model in which Blm10 proteasome-mediated turnover of Dnm1 is required for the maintenance of mitochondrial function
Title: Proteasomes associated with the Blm10 activator protein antagonize mitochondrial fission through degradation of the fission protein Dnm1.
the Insert B domain of the Dnm1 guanosine triphosphatase (a DRP) contains a novel motif required for association with the mitochondrial adaptor Mdv1
Title: A novel motif in the yeast mitochondrial dynamin Dnm1 is essential for adaptor binding and membrane recruitment.
The de novo synthesis of peroxisomes is independent of the GTPases Vps1p and Dnm1p, two proteins required for peroxisome fission.
Title: De novo synthesis of peroxisomes upon mitochondrial targeting of Pex3p.
Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes.
Title: Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes.
Mdv1 played a postmitochondrial targeting role in division by interacting & coassembling with the GTP-bound form of Dnm1; this regulated interaction nucleated & promoted self-assembly of Dnm1 into helical structures which drive membrane scission
Title: Mechanistic analysis of a dynamin effector.
findings show that Dnm1p-dependent peroxisome fission requires Fis1p, Caf4p and Mdv1p
Title: Dnm1p-dependent peroxisome fission requires Caf4p, Mdv1p and Fis1p.
Woronin bodies emerge after the formation of a HEX1 core crystal within peroxisomes followed by Vps1p- and Dnm1p-mediated fission
Title: Dynamin-like protein-dependent formation of Woronin bodies in Saccharomyces cerevisiae upon heterologous expression of a single protein.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular distribution of mitochondria	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular distribution of mitochondria	IGI Inferred from Genetic Interaction more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within membrane bending	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion inheritance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in peroxisome fission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peroxisome organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dynamin-related GTPase DNM1

NP_013100.1

EC 3.6.5.5

Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and inheritance; self assembles on the cytoplasmic face of mitochondrial tubules at sites where division will occur; participates in endocytosis and regulates peroxisome fission along with Vps1p; mutants in the human ortholog DNM1L, which mediates mitochondrial fission, peroxisomal division, autophagy, and mitophagy, are associated with slowly progressive infantile encephalopathy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

147890..150163

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181821.1 → NP_013100.1 TPA: dynamin-related GTPase DNM1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013100.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VY02, P54861

UniProtKB/TrEMBL

A7A0Q5, B3LTG5, B5VMU1, C7GPF8, C8ZCX2, G2WIJ4, N1NYY6

Conserved Domains (3) summary

smart00302
Location:665 → 756

GED; Dynamin GTPase effector domain

cd08771
Location:26 → 333

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:255 → 540

Dynamin_M; Dynamin central region