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    RKM5 S-adenosylmethionine-dependent methyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850828, updated on 27-Dec-2024

    Summary

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    Official Symbol
    RKM5
    Official Full Name
    S-adenosylmethionine-dependent methyltransferase
    Primary source
    SGD:S000004127
    Locus tag
    YLR137W
    See related
    AllianceGenome:SGD:S000004127; FungiDB:YLR137W; VEuPathDB:YLR137W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables S-adenosylmethionine-dependent methyltransferase activity. Involved in protein methylation. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RKM5 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (417006..418109)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Slx4p Neighboring gene Tis11p Neighboring gene Nha1p Neighboring gene Sls1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ribosomal l1 protuberance in yeast is methylated on a lysine residue catalyzed by a seven-beta-strand methyltransferase. Webb KJ, et al. J Biol Chem, 2011 May 27. PMID 21460220, Free PMC Article
    2. Multiple Motif Scanning to identify methyltransferases from the yeast proteome. Petrossian TC, et al. Mol Cell Proteomics, 2009 Jul. PMID 19351663, Free PMC Article
    3. Ribosomal protein methyltransferases in the yeast Saccharomyces cerevisiae: Roles in ribosome biogenesis and translation. Al-Hadid Q, et al. Biochem Biophys Res Commun, 2016 Feb 12. PMID 26801560, Free PMC Article
    4. Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A. Sutter BM, et al. Cell, 2013 Jul 18. PMID 23870128, Free PMC Article
    5. The sensitivity of the yeast, Saccharomyces cerevisiae, to acetic acid is influenced by DOM34 and RPL36A. Samanfar B, et al. PeerJ, 2017. PMID 29158977, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We propose that the YLR137W gene be given the standard name RKM5 (ribosomal lysine (K) methyltransferase 5).
      Title: The ribosomal l1 protuberance in yeast is methylated on a lysine residue catalyzed by a seven-beta-strand methyltransferase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    S-adenosylmethionine-dependent methyltransferase
    NP_013238.1
    • Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      417006..418109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182024.1 → NP_013238.1  TPA: S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013238.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A136, B3LT98, B5VN66, C7GMI9, D6VYD2, Q12367
      UniProtKB/TrEMBL
      N1P177
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12367.1

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