NUP2 nucleoporin NUP2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NUP2
Official Full Name: nucleoporin NUP2
Primary source: SGD:S000004327
Locus tag: YLR335W
See related: AllianceGenome:SGD:S000004327; FungiDB:YLR335W; VEuPathDB:YLR335W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables small GTPase binding activity. A structural constituent of nuclear pore. Involved in several processes, including constitutive heterochromatin formation; nucleocytoplasmic transport; and post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery. Located in mitochondrion. Part of nuclear pore cytoplasmic filaments and nuclear pore nuclear basket. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See NUP2 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (797430..799592)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Meiotic nuclear pore complex remodeling provides key insights into nuclear basket organization.
Title: Meiotic nuclear pore complex remodeling provides key insights into nuclear basket organization.
The Nup2 meiotic-autonomous region relieves inhibition of Nup60 to promote progression of meiosis and sporulation in Saccharomyces cerevisiae.
Title: The Nup2 meiotic-autonomous region relieves inhibition of Nup60 to promote progression of meiosis and sporulation in Saccharomyces cerevisiae.
Co-translational assembly and localized translation of nucleoporins in nuclear pore complex biogenesis.
Title: Co-translational assembly and localized translation of nucleoporins in nuclear pore complex biogenesis.
While Nup60 is the unique target of genotoxic stress within the nuclear basket that probably belongs to the SUMO-mediated DNA damage response pathway, both Nup2 and Nup60 show a dramatic increase in SUMOylation upon osmotic stress, with Nup2 SUMOylation being enhanced in Nup60 SUMO-deficient mutant yeast strains.
Title: SUMOylation of the nuclear pore complex basket is involved in sensing cellular stresses.
Deleting NUP2 affects meiotic progression and spore viability. 125 aa region of Nup2 is necessary and sufficient for its meiotic function.
Title: The Nucleoporin Nup2 Contains a Meiotic-Autonomous Region that Promotes the Dynamic Chromosome Events of Meiosis.
Nup2p and the Ran guanylyl-nucleotide exchange factor, Prp20p, interact at specific chromatin regions and enable the NPC to play an active role in chromatin organization by facilitating the transition of chromatin between activity states.
Title: The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IGI Inferred from Genetic Interaction more info	PubMed
enables structural constituent of nuclear pore	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in NLS-bearing protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in NLS-bearing protein import into nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in NLS-bearing protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular transport	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus in response to heat stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in poly(A)+ mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein export from nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein export from nucleus	IPI Inferred from Physical Interaction more info	PubMed
involved_in protein localization to nuclear inner membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in silent mating-type cassette heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in subtelomeric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore cytoplasmic filaments	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore nuclear basket	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleoporin NUP2

NP_013439.1

Nucleoporin involved in nucleocytoplasmic transport; binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization; involved with Nup60p in nuclear basket remodeling during meiosis; Cdc5p-mediated phosphorylation of Nup60p leads to detachment and reattachment of nuclear basket

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

797430..799592

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182224.1 → NP_013439.1 TPA: nucleoporin NUP2 [Saccharomyces cerevisiae S288C]

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYX5, P32499, Q06130

UniProtKB/TrEMBL

B3RHK8, B5VNM6, C7GUM1, G2WJF4, N1P016

Conserved Domains (3) summary

smart00160
Location:588 → 715

RanBD; Ran-binding domain

PRK08581
Location:233 → 486

PRK08581; amidase domain-containing protein

pfam08911
Location:3 → 70

NUP50; NUP50 (Nucleoporin 50 kDa)