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    AVO2 Avo2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855090, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AVO2
    Official Full Name
    Avo2p
    Primary source
    SGD:S000004672
    Locus tag
    YMR068W
    See related
    AllianceGenome:SGD:S000004672; FungiDB:YMR068W; VEuPathDB:YMR068W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in establishment or maintenance of actin cytoskeleton polarity and regulation of cell growth. Located in plasma membrane. Part of TORC2 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AVO2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (406304..407584)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Sov1p Neighboring gene Ubx4p Neighboring gene N-terminal L-serine N(alpha)-acetyltransferase NatD Neighboring gene Mot3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dysfunction of Avo3, an essential component of target of rapamycin complex 2, induces ubiquitin-proteasome-dependent downregulation of Avo2 in Saccharomyces cerevisiae. Chen PK, et al. Biochem Biophys Res Commun, 2024 Jul 12. PMID 38718572
    2. Molecular organization of target of rapamycin complex 2. Wullschleger S, et al. J Biol Chem, 2005 Sep 2. PMID 16002396
    3. Analysis of the roles of phosphatidylinositol-4,5-bisphosphate and individual subunits in assembly, localization, and function of Saccharomyces cerevisiae target of rapamycin complex 2. Martinez Marshall MN, et al. Mol Biol Cell, 2019 Jun 1. PMID 30969890, Free PMC Article
    4. TORC2 and eisosomes are spatially interdependent, requiring optimal level of phosphatidylinositol 4, 5-bisphosphate for their integrity. Bartlett K, et al. J Biosci, 2015 Jun. PMID 25963258
    5. Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Pan Y, et al. Cell Metab, 2011 Jun 8. PMID 21641548, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dysfunction of Avo3, an essential component of target of rapamycin complex 2, induces ubiquitin-proteasome-dependent downregulation of Avo2 in Saccharomyces cerevisiae.
      Title: Dysfunction of Avo3, an essential component of target of rapamycin complex 2, induces ubiquitin-proteasome-dependent downregulation of Avo2 in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment or maintenance of actin cytoskeleton polarity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of cell growth IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TORC2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Avo2p
    NP_013784.1
    • Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; PM retention is dependent on Avo3p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      406304..407584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182566.1 → NP_013784.1  TPA: Avo2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013784.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZP2, Q04749
      UniProtKB/TrEMBL
      A6ZMC7, B3LLW1, C7GL56, C8ZES0, N1P087
      Conserved Domains (3) summary
      COG0666
      Location:37 → 185
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:75 → 106
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:9 → 60
      Ank_4; Ankyrin repeats (many copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04749.1

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