ALT2 alanine transaminase ALT2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ALT2
Official Full Name: alanine transaminase ALT2
Primary source: SGD:S000002518
Locus tag: YDR111C
See related: AllianceGenome:SGD:S000002518; FungiDB:YDR111C; VEuPathDB:YDR111C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables pyridoxal phosphate binding activity. Predicted to be involved in L-alanine catabolic process and biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spastic paraplegia and microcephaly. Orthologous to several human genes including GPT (glutamic--pyruvic transaminase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ALT2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (678241..679764, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Paralogous ALT1 and ALT2 retention and diversification have generated catalytically active and inactive aminotransferases in Saccharomyces cerevisiae
Title: Paralogous ALT1 and ALT2 retention and diversification have generated catalytically active and inactive aminotransferases in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables L-alanine:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info
enables transaminase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in L-alanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alanine transaminase ALT2

NP_010396.1

EC 2.6.1.2

Catalytically inactive alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p; ALT2 has a paralog, ALT1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

678241..679764 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180419.1 → NP_010396.1 TPA: alanine transaminase ALT2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010396.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VS97, P52892, Q66RF8

UniProtKB/TrEMBL

A6ZY74, B3LGG4, C8Z527, G2WAL4, N1P6L1

Conserved Domains (1) summary

PTZ00377
Location:26 → 505

PTZ00377; alanine aminotransferase; Provisional