ARG82 inositol polyphosphate multikinase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ARG82
Official Full Name: inositol polyphosphate multikinase
Primary source: SGD:S000002580
Locus tag: YDR173C
See related: AllianceGenome:SGD:S000002580; FungiDB:YDR173C; VEuPathDB:YDR173C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ARGR3; IPK2
Summary: Enables 1-phosphatidylinositol-3-kinase activity; inositol phosphate kinase activity; and protein-macromolecule adaptor activity. Involved in several processes, including organophosphate biosynthetic process; protein stabilization; and regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human IP6K1 (inositol hexakisphosphate kinase 1); IP6K2 (inositol hexakisphosphate kinase 2); and IP6K3 (inositol hexakisphosphate kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ARG82 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (810565..811632, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IPK2-dependent transcriptional control has been described in Saccharomyces cerevisiae.
Title: Inositol phosphate multikinase dependent transcriptional control.
Studies indicate that the inositol-polyphosphate multikinase (IPMK) homologue, Arg82, is the sole inositol-trisphosphate kinase.
Title: Arginine transcriptional response does not require inositol phosphate synthesis.
Replacement of critical side chains in the inositol binding site suggests how modification of substrate recognition motifs determines enzymatic substrate preference and catalysis.
Title: Crystal structure of inositol phosphate multikinase 2 and implications for substrate specificity.
Plc1p, Arg82p, and Kcs1p are enzymes involved in inositol pyrophosphate synthesis and are essential for phosphate regulation and polyphosphate accumulation
Title: Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,5,6-pentakisphosphate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,6-tetrakisphosphate 5-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,4,5-trisphosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,4,5-trisphosphate 3-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,4,5-trisphosphate 3-kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables inositol-1,4,5-trisphosphate 6-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,4,5-trisphosphate 6-kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in arginine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in inositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of arginine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inositol polyphosphate multikinase

NP_010458.3

EC 2.7.1.127

EC 2.7.1.151

Inositol polyphosphate multikinase (IPMK); sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates genes responsive to arginine, phosphate, and nitrogen; needed by most [PSI+] variants for prion propagation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

810565..811632 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180480.3 → NP_010458.3 TPA: inositol polyphosphate multikinase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010458.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSF5, E9P8S7, P07250

UniProtKB/TrEMBL

A6ZYD1, B3LGB0, C7GN24

Conserved Domains (1) summary

pfam03770
Location:114 → 352

IPK; Inositol polyphosphate kinase