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    CBT1 Cbt1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853673, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CBT1
    Official Full Name
    Cbt1p
    Primary source
    SGD:S000001691
    Locus tag
    YKL208W
    See related
    AllianceGenome:SGD:S000001691; FungiDB:YKL208W; VEuPathDB:YKL208W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SOC1
    Summary
    Involved in cytochrome complex assembly; mRNA processing; and mRNA stabilization. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CBT1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (47157..47972)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette a-factor transporter STE6 Neighboring gene tRNA-Thr Neighboring gene Emc3p Neighboring gene Add66p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel nuclear gene, CBT1, essential for mitochondrial cytochrome b formation: terminal processing of mRNA and intron dependence. Rieger KJ, et al. Curr Genet, 1997 Sep. PMID 9339340
    2. CBT1 interacts genetically with CBP1 and the mitochondrially encoded cytochrome b gene and is required to stabilize the mature cytochrome b mRNA of Saccharomyces cerevisiae. Ellis TP, et al. Genetics, 2005 Nov. PMID 16118200, Free PMC Article
    3. Dbf2 is implicated in a Cbt1-dependent pathway following a shift from glucose to galactose or non-fermentable carbon sources in Saccharomyces cerevisiae. Grandin N, et al. Mol Gen Genet, 1999 Mar. PMID 10102376
    4. Suppressor analysis of mutations in the 5'-untranslated region of COB mRNA identifies components of general pathways for mitochondrial mRNA processing and decay in Saccharomyces cerevisiae. Chen W, et al. Genetics, 1999 Apr. PMID 10101159, Free PMC Article
    5. ATG18 and FAB1 are involved in dehydration stress tolerance in Saccharomyces cerevisiae. López-Martínez G, et al. PLoS One, 2015. PMID 25803831, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Null strains have defects in 5'-end processing of precursor cytochrome b mRNA to the mature form.
      Title: CBT1 interacts genetically with CBP1 and the mitochondrially encoded cytochrome b gene and is required to stabilize the mature cytochrome b mRNA of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytochrome complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytochrome complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cbt1p
    NP_012714.1
    • Protein involved in 5' RNA end processing; substrates include mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      47157..47972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179773.1 → NP_012714.1  TPA: Cbt1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012714.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWZ5, P36038, Q6Q574
      UniProtKB/TrEMBL
      G2WHI6, N1P0A3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36038.1

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