U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    LOT6 flavin-dependent quinone reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850698, updated on 9-Dec-2024

    Summary

    Official Symbol
    LOT6
    Official Full Name
    flavin-dependent quinone reductase
    Primary source
    SGD:S000004001
    Locus tag
    YLR011W
    See related
    AllianceGenome:SGD:S000004001; FungiDB:YLR011W; VEuPathDB:YLR011W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables NAD(P)H dehydrogenase (quinone) activity. Involved in apoptotic process and cellular response to oxidative stress. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LOT6 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (169103..169678)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Ten1p Neighboring gene tRNA-Ser Neighboring gene uncharacterized protein Neighboring gene Gat3p

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables FMN reductase (NAD(P)H) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables FMN reductase (NADH) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables FMN reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD(P)H dehydrogenase (quinone) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD(P)H dehydrogenase (quinone) activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    flavin-dependent quinone reductase
    NP_013111.1
    • FMN-dependent NAD(P)H:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      169103..169678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181898.1NP_013111.1  TPA: flavin-dependent quinone reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013111.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY13, Q07923
      UniProtKB/TrEMBL
      A7A0R6, B3LSY4, B5VMV3, C7GXF7, C8ZCY3, G2WIK5, N1P0D3
      Conserved Domains (1) summary
      COG0431
      Location:1189
      SsuE; NAD(P)H-dependent FMN reductase [Energy production and conversion]