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    IOC2 Ioc2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850784, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IOC2
    Official Full Name
    Ioc2p
    Primary source
    SGD:S000004085
    Locus tag
    YLR095C
    See related
    AllianceGenome:SGD:S000004085; FungiDB:YLR095C; VEuPathDB:YLR095C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to ATP hydrolysis activity; DNA binding activity; and nucleosome binding activity. Involved in chromatin remodeling. Part of Isw1b complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IOC2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (329677..332115, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Nyv1p Neighboring gene Gis3p Neighboring gene serine/threonine protein kinase KIN2 Neighboring gene SCF ubiquitin ligase complex subunit HRT3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isw1 acts independently of the Isw1a and Isw1b complexes in regulating transcriptional silencing at the ribosomal DNA locus in Saccharomyces cerevisiae. Mueller JE, et al. J Mol Biol, 2007 Aug 3. PMID 17561109, Free PMC Article
    2. Yeast Isw1p forms two separable complexes in vivo. Vary JC Jr, et al. Mol Cell Biol, 2003 Jan. PMID 12482963, Free PMC Article
    3. Termination of the unfolded protein response is guided by ER stress-induced HAC1 mRNA nuclear retention. Matabishi-Bibi L, et al. Nat Commun, 2022 Oct 25. PMID 36284099, Free PMC Article
    4. Dependency of ISW1a chromatin remodeling on extranucleosomal DNA. Gangaraju VK, et al. Mol Cell Biol, 2007 Apr. PMID 17283061, Free PMC Article
    5. Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes. Stockdale C, et al. J Biol Chem, 2006 Jun 16. PMID 16606615, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to nucleosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Isw1b complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ioc2p
    NP_013196.1
    • Subunit of the Isw1b complex; exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing; contains a PHD finger motif; other complex members are Isw1p and Ioc4p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      329677..332115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181982.1 → NP_013196.1  TPA: Ioc2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013196.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY95, Q12072
      UniProtKB/TrEMBL
      A7A0Z9, N1P134
      Conserved Domains (1) summary
      cl22851
      Location:556 → 584
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12072.1

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