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    BOR1 Bor1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855446, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BOR1
    Official Full Name
    Bor1p
    Primary source
    SGD:S000005219
    Locus tag
    YNL275W
    See related
    AllianceGenome:SGD:S000005219; FungiDB:YNL275W; VEuPathDB:YNL275W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables borate efflux transmembrane transporter activity. Involved in borate transport and protein targeting to vacuole. Located in fungal-type vacuole and plasma membrane. Used to study anemia; hereditary spherocytosis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital hemolytic anemia (multiple); corneal dystrophy-perceptive deafness syndrome; corneal endothelial dystrophy (multiple); osteopetrosis; and renal tubular acidosis. Orthologous to several human genes including SLC4A9 (solute carrier family 4 member 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BOR1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (119268..120998)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene homoserine O-acetyltransferase Neighboring gene glyoxylate reductase Neighboring gene Tof1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Boron-dependent regulation of translation through AUGUAA sequence in yeast. Tsednee M, et al. Yeast, 2020 Dec. PMID 33289202
    2. Protein-Lipid Interactions Stabilize the Oligomeric State of BOR1p from Saccharomyces cerevisiae. Pyle E, et al. Anal Chem, 2019 Oct 15. PMID 31513392
    3. Structure of the SLC4 transporter Bor1p in an inward-facing conformation. Coudray N, et al. Protein Sci, 2017 Jan. PMID 27717063, Free PMC Article
    4. Isolation of Arabidopsis thaliana cDNAs that confer yeast boric acid tolerance. Nozawa A, et al. Biosci Biotechnol Biochem, 2006 Jul. PMID 16861809
    5. Saccharomyces cerevisiae Bor1p is a boron exporter and a key determinant of boron tolerance. Takano J, et al. FEMS Microbiol Lett, 2007 Feb. PMID 17166224

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural and functional insights into the mechanism of action of plant borate transporters.
      Title: Structural and functional insights into the mechanism of action of plant borate transporters.
    2. Unlikely that the main function of Bor1 is boron efflux, but may have role in vacuolar dynamics.
      Title: Transport and regulatory characteristics of the yeast bicarbonate transporter homolog Bor1p.
    3. These results suggest that, in addition to the efflux boron transporter BOR1, DUR3 and FPS1 play important roles in regulating the cellular boron concentration.
      Title: Roles of BOR1, DUR3, and FPS1 in boron transport and tolerance in Saccharomyces cerevisiae.
    4. Bor1p is a plasma membrane boron exporter and a key determinant of boron tolerance.
      Title: Saccharomyces cerevisiae Bor1p is a boron exporter and a key determinant of boron tolerance.
    5. enolase stimulates vacuole fusion and enolase and Bor1p regulate selective protein trafficking to the vacuole
      Title: Enolase activates homotypic vacuole fusion and protein transport to the vacuole in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables borate efflux transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables borate efflux transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables borate efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables solute:inorganic anion antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in borate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in borate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in borate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in borate transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic anion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in fungal-type vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bor1p
    NP_014124.1
    • Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      119268..120998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183113.1 → NP_014124.1  TPA: Bor1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014124.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0R9, P53838
      UniProtKB/TrEMBL
      A6ZRG9, B3LPB4, B5VQD9, C7GP88, C8ZGP7, G2WLJ1
      Conserved Domains (1) summary
      cl23746
      Location:61 → 475
      Xan_ur_permease; Permease family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53838.1

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