SGT1 co-chaperone SGT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SGT1
Official Full Name: co-chaperone SGT1
Primary source: SGD:S000005583
Locus tag: YOR057W
See related: AllianceGenome:SGD:S000005583; FungiDB:YOR057W; VEuPathDB:YOR057W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein-folding chaperone binding activity and protein-macromolecule adaptor activity. Involved in kinetochore assembly and protein quality control for misfolded or incompletely synthesized proteins. Part of ubiquitin ligase complex. Is active in cytosol and endoplasmic reticulum. Orthologous to human SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SGT1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (432186..433373)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Report the importance of Hsp90/Sgt1 system in controlling cell plasticity.
Title: The Plasticity of the Hsp90 Co-chaperone System.
overexpression of other co-chaperones further disrupts the essential functions of Cns1 and Sgt1. However, the specificity of the negative effects indicates that only a subset of co-chaperones competes with Sgt1 or Cns1 for binding to Hsp90.
Title: Mutation of essential Hsp90 co-chaperones SGT1 or CNS1 renders yeast hypersensitive to overexpression of other co-chaperones.
protein kinase CK2 phosphorylates Ser(361) on Sgt1, and this phosphorylation inhibits Sgt1 dimerization
Title: Sgt1 dimerization is negatively regulated by protein kinase CK2-mediated phosphorylation at Ser361.
Sgt1 dimerization is required for kinetochore assembly.
Title: Sgt1 dimerization is required for yeast kinetochore assembly.
Data show that the amino terminus of Sgt1p interacts with CBF3 subunits Skp1p and Ctf13p.
Title: The interaction between Sgt1p and Skp1p is regulated by HSP90 chaperones and is required for proper CBF3 assembly.
Sgt1p acts as a "client adaptor" recruiting specific clients to Hsp82p co-chaperone complexes
Title: Sgt1p is a unique co-chaperone that acts as a client adaptor to link Hsp90 to Skp1p.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein-folding chaperone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in kinetochore assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in protein quality control for misfolded or incompletely synthesized proteins	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
part_of ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: co-chaperone SGT1

NP_014700.1

Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

432186..433373

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183476.1 → NP_014700.1 TPA: co-chaperone SGT1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014700.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2C0, E9P8U7, Q08446

UniProtKB/TrEMBL

C7GSN0, G2WMT5, N1NVR5

Conserved Domains (2) summary

COG5091
Location:10 → 395

SGT1; Suppressor of G2 allele of skp1 and related proteins [General function prediction only]

sd00006
Location:37 → 77

TPR; TPR repeat [structural motif]