PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PKMYT1provided by HGNC
Official Full Name: protein kinase, membrane associated tyrosine/threonine 1provided by HGNC
Primary source: HGNC:HGNC:29650
See related: Ensembl:ENSG00000127564 MIM:602474; AllianceGenome:HGNC:29650
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MYT1; PPP1R126
Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Expression: Broad expression in testis (RPKM 14.8), bone marrow (RPKM 10.4) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (2972808..2980446, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (2999487..3007174, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (3022809..3030447, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PKMYT1 Promotes Epithelial-Mesenchymal Transition Process in Triple-Negative Breast Cancer by Activating Notch Signaling.
Title: PKMYT1 Promotes Epithelial-Mesenchymal Transition Process in Triple-Negative Breast Cancer by Activating Notch Signaling.
PKMYT1: A Potential Target for CCNE1 Amplificated Colorectal Tumors.
Title: PKMYT1: A Potential Target for CCNE1 Amplificated Colorectal Tumors.
ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer.
Title: ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer.
PKMYT1 inhibits lung adenocarcinoma progression by abrogating AKT1 activity.
Title: PKMYT1 inhibits lung adenocarcinoma progression by abrogating AKT1 activity.
Knockdown of PKMYT1 is associated with autophagy inhibition and apoptosis induction and suppresses tumor progression in hepatocellular carcinoma.
Title: Knockdown of PKMYT1 is associated with autophagy inhibition and apoptosis induction and suppresses tumor progression in hepatocellular carcinoma.
KDM2B mediates the Wnt/beta-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer.
Title: KDM2B mediates the Wnt/β-catenin pathway through transcriptional activation of PKMYT1 via microRNA-let-7b-5p/EZH2 to affect the development of non-small cell lung cancer.
CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition.
Title: CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition.
Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification.
Title: Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification.
LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway.
Title: LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway.
PKMYT1, exacerbating the progression of clear cell renal cell carcinoma, is implied as a biomarker for the diagnosis and prognosis.
Title: PKMYT1, exacerbating the progression of clear cell renal cell carcinoma, is implied as a biomarker for the diagnosis and prognosis.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of the metabolic syndrome in Indian Asian men. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484440

RH80840 (e-PCR)
- UniSTS:88154

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	TAS Traceable Author Statement more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of G2/M transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
involved_in regulation of mitotic nuclear division	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Names: myt1 kinase; protein phosphatase 1, regulatory subunit 126

NP_001245379.1

EC 2.7.11.1

NP_001245380.1

EC 2.7.11.1

NP_004194.3

EC 2.7.11.1

NP_872629.1

EC 2.7.11.1

XP_011521036.1

EC 2.7.11.1

XP_011521037.1

EC 2.7.11.1

XP_024306258.1

EC 2.7.11.1

XP_047290824.1

EC 2.7.11.1

XP_047290825.1

EC 2.7.11.1

XP_047290826.1

EC 2.7.11.1

XP_047290827.1

EC 2.7.11.1

XP_047290828.1

EC 2.7.11.1

XP_047290829.1

EC 2.7.11.1

XP_047290830.1

EC 2.7.11.1

XP_054170295.1

EC 2.7.11.1

XP_054170296.1

EC 2.7.11.1

XP_054170297.1

EC 2.7.11.1

XP_054170298.1

EC 2.7.11.1

XP_054170299.1

EC 2.7.11.1

XP_054170300.1

EC 2.7.11.1

XP_054170301.1

EC 2.7.11.1

XP_054170302.1

EC 2.7.11.1

XP_054170303.1

EC 2.7.11.1

XP_054170304.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001258450.2 → NP_001245379.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 3

See identical proteins and their annotated locations for NP_001245379.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AK301926, BQ017689, DB111506

Consensus CDS

CCDS58415.1

UniProtKB/TrEMBL

Q0IJ49

Related

ENSP00000460868.1, ENST00000574730.5

Conserved Domains (2) summary

smart00220
Location:41 → 288

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14050
Location:39 → 288

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
NM_001258451.2 → NP_001245380.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 4

See identical proteins and their annotated locations for NP_001245380.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK097642, AK301926, BQ017689, DB111506

Consensus CDS

CCDS58414.1

UniProtKB/TrEMBL

Q0IJ49

Related

ENSP00000458943.1, ENST00000574385.5

Conserved Domains (2) summary

smart00220
Location:101 → 348

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14050
Location:99 → 348

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
NM_004203.5 → NP_004194.3 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1

See identical proteins and their annotated locations for NP_004194.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

BC121161, BQ017689, DB009060

Consensus CDS

CCDS10486.1

UniProtKB/Swiss-Prot

B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640

UniProtKB/TrEMBL

Q0IJ49

Related

ENSP00000262300.8, ENST00000262300.13

Conserved Domains (1) summary

cd14050
Location:108 → 357

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
NM_182687.3 → NP_872629.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 2

See identical proteins and their annotated locations for NP_872629.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK098452, BQ017689, DB009060

Consensus CDS

CCDS45391.1

UniProtKB/TrEMBL

A6NHV6, B4DG26

Related

ENSP00000397739.2, ENST00000440027.6

Conserved Domains (2) summary

smart00220
Location:110 → 357

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14050
Location:108 → 357

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

2972808..2980446 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011522735.4 → XP_011521037.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X3

See identical proteins and their annotated locations for XP_011521037.1

UniProtKB/TrEMBL

Q0IJ49

Related

ENSP00000459123.1, ENST00000573944.5

Conserved Domains (2) summary

smart00220
Location:101 → 348

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14050
Location:99 → 348

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
XM_047434868.1 → XP_047290824.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1
XM_011522734.4 → XP_011521036.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

See identical proteins and their annotated locations for XP_011521036.1

UniProtKB/Swiss-Prot

B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640

UniProtKB/TrEMBL

Q0IJ49

Conserved Domains (1) summary

cd14050
Location:108 → 357

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
XM_047434869.1 → XP_047290825.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1
XM_047434873.1 → XP_047290829.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

UniProtKB/Swiss-Prot

B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640
XM_047434871.1 → XP_047290827.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1
XM_047434874.1 → XP_047290830.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

UniProtKB/Swiss-Prot

B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640
XM_047434872.1 → XP_047290828.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1
XM_024450490.2 → XP_024306258.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

UniProtKB/Swiss-Prot

B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640

UniProtKB/TrEMBL

Q0IJ49

Conserved Domains (1) summary

cd14050
Location:108 → 357

PKc_Myt1; Catalytic domain of the Dual-specificity protein kinase, Myt1
XM_047434870.1 → XP_047290826.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

2999487..3007174 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054314328.1 → XP_054170303.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

UniProtKB/Swiss-Prot

B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640
XM_054314322.1 → XP_054170297.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1
XM_054314329.1 → XP_054170304.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X3
XM_054314320.1 → XP_054170295.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1
XM_054314325.1 → XP_054170300.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

UniProtKB/Swiss-Prot

B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640
XM_054314321.1 → XP_054170296.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1
XM_054314326.1 → XP_054170301.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

UniProtKB/Swiss-Prot

B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640
XM_054314323.1 → XP_054170298.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1
XM_054314327.1 → XP_054170302.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2

UniProtKB/Swiss-Prot

B3KUN8, B4DXD4, D3DUA4, F8W164, I3L1V2, O14731, Q7LE24, Q8TCM9, Q99640
XM_054314324.1 → XP_054170299.1 membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1