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    adam19a ADAM metallopeptidase domain 19a [ Danio rerio (zebrafish) ]

    Gene ID: 565342, updated on 4-Jan-2025

    Summary

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    Official Symbol
    adam19aprovided by ZNC
    Official Full Name
    ADAM metallopeptidase domain 19aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070813-1
    See related
    AllianceGenome:ZFIN:ZDB-GENE-070813-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and rhinitis. Orthologous to several human genes including ADAM33 (ADAM metallopeptidase domain 33). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See adam19a in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (61303113..61531789)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (60992768..61221637)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene RELT like 1 Neighboring gene RWD domain containing 4 Neighboring gene uncharacterized LOC137496233 Neighboring gene uncharacterized LOC101883943 Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 4 Neighboring gene uncharacterized LOC137496234

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ADAM12-deficient zebrafish exhibit retardation in body growth at the juvenile stage without developmental defects. Tokumasu Y, et al. Dev Growth Differ, 2016 May. PMID 27185351
    2. The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. Huxley-Jones J, et al. BMC Evol Biol, 2007 Apr 17. PMID 17439641, Free PMC Article
    3. The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. Lang I, et al. Int J Mol Sci, 2020 Aug 9. PMID 32784920, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 19
    Names
    a disintegrin and metalloproteinase domain 19a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      61303113..61531789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172361.5 → XP_005172418.1  disintegrin and metalloproteinase domain-containing protein 19

      UniProtKB/TrEMBL
      A0A8M2BJN9, A0A8M9Q360
      Conserved Domains (6) summary
      smart00608
      Location:506 → 651
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:214 → 411
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:440 → 503
      Disintegrin; Disintegrin
      pfam01421
      Location:214 → 413
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:77 → 158
      Pep_M12B_propep; Reprolysin family propeptide
      pfam07974
      Location:663 → 686
      EGF_2; EGF-like domain
    Nucleotide Protein
    Heading Accession and Version

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