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    pik3r2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) [ Danio rerio (zebrafish) ]

    Gene ID: 404211, updated on 4-Jan-2025

    Summary

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    Official Symbol
    pik3r2provided by ZNC
    Official Full Name
    phosphoinositide-3-kinase, regulatory subunit 2 (beta)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040309-1
    See related
    Ensembl:ENSDARG00000018060 AllianceGenome:ZFIN:ZDB-GENE-040309-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Is expressed in skeletal muscle. Human ortholog(s) of this gene implicated in pancreatic ductal adenocarcinoma. Orthologous to human PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See pik3r2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (24693485..24755347)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (25037644..25095091)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene Growth differentiation factor-15 Neighboring gene microtubule associated serine/threonine kinase 3a Neighboring gene uncharacterized LOC101882114 Neighboring gene IFI30 lysosomal thiol reductase a Neighboring gene MPV17 mitochondrial inner membrane protein like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phosphoinositide 3-kinase is required for process outgrowth and cell polarization of gastrulating mesendodermal cells. Montero JA, et al. Curr Biol, 2003 Aug 5. PMID 12906787
    2. Altering PI3K-Akt signalling in zebrafish embryos affects PTEN phosphorylation and gastrulation. Finkielsztein A, et al. Biol Cell, 2009 Aug 25. PMID 19515017
    3. Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome. Wu Y, et al. Orphanet J Rare Dis, 2020 Apr 22. PMID 32321550, Free PMC Article
    4. Identification of mundoserone by zebrafish in vivo screening as a natural product with anti-angiogenic activity. Chen K, et al. Exp Ther Med, 2018 Dec. PMID 30542405, Free PMC Article
    5. In vivo Screening of Natural Products Against Angiogenesis and Mechanisms of Anti-Angiogenic Activity of Deoxysappanone B 7,4'-Dimethyl Ether. Chen K, et al. Drug Des Devel Ther, 2020. PMID 32801645, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex, class IA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 3-kinase regulatory subunit beta
    Names
    phosphoinositide-3-kinase, regulatory subunit, polypeptide 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212822.2 → NP_997987.2  phosphatidylinositol 3-kinase regulatory subunit beta

      See identical proteins and their annotated locations for NP_997987.2

      Status: VALIDATED

      Source sequence(s)
      CABZ01043807, CR769774, EB913392
      UniProtKB/TrEMBL
      A0A8M1PI32, B3DHG9
      Related
      ENSDARP00000130009.1, ENSDART00000170467.2
      Conserved Domains (6) summary
      cd09930
      Location:616 → 720
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:326 → 433
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd11909
      Location:6 → 79
      SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
      cd12926
      Location:438 → 598
      iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
      pfam16454
      Location:437 → 596
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
      cl02570
      Location:113 → 298
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      24693485..24755347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163369.5 → XP_005163426.1  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1

      See identical proteins and their annotated locations for XP_005163426.1

      UniProtKB/TrEMBL
      A0A8M1PI32, B3DHG9
      Related
      ENSDARP00000118451.2, ENSDART00000147207.3
      Conserved Domains (6) summary
      cd09930
      Location:616 → 720
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:326 → 433
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd11909
      Location:6 → 79
      SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
      cd12926
      Location:438 → 598
      iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
      pfam16454
      Location:437 → 596
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
      cl02570
      Location:113 → 298
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    2. XM_005163370.5 → XP_005163427.1  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1

      See identical proteins and their annotated locations for XP_005163427.1

      UniProtKB/TrEMBL
      A0A8M1PI32, B3DHG9
      Conserved Domains (6) summary
      cd09930
      Location:616 → 720
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:326 → 433
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd11909
      Location:6 → 79
      SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
      cd12926
      Location:438 → 598
      iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
      pfam16454
      Location:437 → 596
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
      cl02570
      Location:113 → 298
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394504.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      118602..160324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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