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    tbrg4 transforming growth factor beta regulator 4 [ Danio rerio (zebrafish) ]

    Gene ID: 562388, updated on 4-Jan-2025

    Summary

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    Official Symbol
    tbrg4provided by ZNC
    Official Full Name
    transforming growth factor beta regulator 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091020-8
    See related
    Ensembl:ENSDARG00000074807 AllianceGenome:ZFIN:ZDB-GENE-091020-8
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial RNA processing and regulation of mitochondrial mRNA stability. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Orthologous to human TBRG4 (transforming growth factor beta regulator 4). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See tbrg4 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (27660006..27677960, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (27725383..27743394, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene GLI pathogenesis-related 2, like Neighboring gene NAC alpha domain containing Neighboring gene STEAP family member 4 Neighboring gene zinc finger protein 804B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history. Castro LF, et al. Proc Biol Sci, 2014 Jan 22. PMID 24307675, Free PMC Article
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of mitochondrial mRNA stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein TBRG4; FAST kinase domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      27660006..27677960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_685771.9 → XP_690863.4  FAST kinase domain-containing protein 4

      UniProtKB/TrEMBL
      A0A8N7UVV2, E7F3K7
      Related
      ENSDARP00000122165.1, ENSDART00000145991.3
      Conserved Domains (3) summary
      smart00952
      Location:563 → 620
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:370 → 437
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:454 → 535
      FAST_2; FAST kinase-like protein, subdomain 2
    Nucleotide Protein Strain
    Heading Accession and Version

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