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    RNF121 ring finger protein 121 [ Homo sapiens (human) ]

    Gene ID: 55298, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RNF121provided by HGNC
    Official Full Name
    ring finger protein 121provided by HGNC
    Primary source
    HGNC:HGNC:21070
    See related
    Ensembl:ENSG00000137522 MIM:620529; AllianceGenome:HGNC:21070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products. [provided by RefSeq, Sep 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 7.3), thyroid (RPKM 7.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RNF121 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (71929046..71997597)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (71855935..71924512)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71640092..71708643)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene XNDC1N-ZNF705EP-ALG1L9P readthrough Neighboring gene XRCC1 N-terminal domain containing 1, N-terminal like Neighboring gene olfactory receptor family 7 subfamily E member 128 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 126 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71660091-71661028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71661029-71661964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5175 Neighboring gene uncharacterized LOC100128494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71725991-71726738 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:71728895-71730094 Neighboring gene interleukin 18 binding protein Neighboring gene nuclear mitotic apparatus protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RNF121 Inhibits Angiogenic Growth Factor Signaling by Restricting Cell Surface Expression of VEGFR-2. Maghsoudlou A, et al. Traffic, 2016 Mar. PMID 26602861, Free PMC Article
    2. Really interesting new gene finger protein 121 is a novel Golgi-localized membrane protein that regulates apoptosis. Zhao Y, et al. Acta Biochim Biophys Sin (Shanghai), 2014 Aug. PMID 24928685
    3. Really interesting new gene finger protein 121 is a tumor suppressor of renal cell carcinoma. Xiang P, et al. Gene, 2018 Nov 15. PMID 30149063
    4. Structure of human glycosylphosphatidylinositol transamidase. Zhang H, et al. Nat Struct Mol Biol, 2022 Mar. PMID 35165458
    5. Integrative analysis of oncogenic fusion genes and their functional impact in colorectal cancer. Choi Y, et al. Br J Cancer, 2018 Jul. PMID 29955133, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we identified and characterised oncogenic fusion genes and their function in CRC, and implicated NAGLU-IKZF3 and RNF121-FOLR2 as novel molecular targets for personalised medicine development.
      Title: Integrative analysis of oncogenic fusion genes and their functional impact in colorectal cancer.
    2. Study found that RNF121 was less expressed in tumor tissues than adjacent normal tissues of renal cell carcinoma (RCC) patients. Overexpression of RNF121 inhibited the growth of human RCC cells in vivo. Moreover, RNF121 impeded the proliferation, migration and invasion of human RCC cells in vitro. In addition, RNF121 was found to activate NF-kappaB signaling pathway via promoting IkappaBalpha degradation in RCC cells.
      Title: Really interesting new gene finger protein 121 is a tumor suppressor of renal cell carcinoma.
    3. Over-expression of RNF121 promoted ubiquitination of VEGFR-2, inhibited its maturation . RNF121 knockdown in primary endothelial cells reduced VEGFR-2 ubiquitination and increased its cell surface level.
      Title: RNF121 Inhibits Angiogenic Growth Factor Signaling by Restricting Cell Surface Expression of VEGFR-2.
    4. These results unveil an unexpected role of Golgi Apparatus and reveal RNF121 as a new player involved in the signaling leading to NF-kappaB activation.
      Title: The E3 ubiquitin ligase RNF121 is a positive regulator of NF-κB activation.
    5. This is the first study to demonstrate that RNF121 is a novel regulator of apoptosis and provides a new potential target for cancer therapy
      Title: Really interesting new gene finger protein 121 is a novel Golgi-localized membrane protein that regulates apoptosis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11099

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin ligase RNF121
    NP_001287855.1
    NP_060790.2
    XP_006718692.1
    XP_006718695.1
    XP_047283189.1
    XP_047283190.1
    XP_054225266.1
    XP_054225267.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300926.2 → NP_001287855.1  E3 ubiquitin ligase RNF121 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has shorter and distinct N- and C-termini compared to isoform a.
      Source sequence(s)
      AL833638, AP002490, DA209781
      Consensus CDS
      CCDS73343.1
      UniProtKB/TrEMBL
      C9JQY5
      Related
      ENSP00000377316.3, ENST00000393713.7

    2. NM_018320.5 → NP_060790.2  E3 ubiquitin ligase RNF121 isoform a

      See identical proteins and their annotated locations for NP_060790.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AI291325, AK023139, AL833638, AP002490, CN392009, DA209781
      Consensus CDS
      CCDS8203.1
      UniProtKB/Swiss-Prot
      B3KSW8, Q6IA57, Q6P449, Q96DB4, Q9H920
      UniProtKB/TrEMBL
      A0PJP0
      Related
      ENSP00000354571.3, ENST00000361756.8
      Conserved Domains (1) summary
      cd16475
      Location:224 → 278
      RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

    RNA

    1. NR_024147.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing an internal coding exon compared to transcript variant 1. If translation initiates at the same codon as used in variant 1, then this results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD). Although a putative alternate AUG site is observed in a different frame downstream of the standard AUG site, it is not likely to be used because it is located within the short ORF available with the standard AUG site (as defined by variant 1). Therefore, the transcript is represented as a non-protein-coding RefSeq.
      Source sequence(s)
      AI291325, AK023139, AL833638, AP002490, CN392009, DA209781
      Related
      ENST00000530137.1

    2. NR_024148.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is missing an internal coding exon and also includes an additional exon compared to transcript variant 1. This results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD). There are no other likely translation initiation sites and so the transcript is represented as a non-protein-coding RefSeq.
      Source sequence(s)
      AI291325, AK023139, AK094508, AL833638, AP002490, CN392009, DA209781, DA694800
      Related
      ENST00000526549.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      71929046..71997597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006718629.2 → XP_006718692.1  E3 ubiquitin ligase RNF121 isoform X1

      See identical proteins and their annotated locations for XP_006718692.1

      UniProtKB/TrEMBL
      A0PJP0
      Conserved Domains (1) summary
      pfam13639
      Location:190 → 240
      zf-RING_2; Ring finger domain

    2. XM_006718632.2 → XP_006718695.1  E3 ubiquitin ligase RNF121 isoform X4

      See identical proteins and their annotated locations for XP_006718695.1

      Conserved Domains (1) summary
      pfam13639
      Location:119 → 169
      zf-RING_2; Ring finger domain

    3. XM_047427233.1 → XP_047283189.1  E3 ubiquitin ligase RNF121 isoform X2

      UniProtKB/TrEMBL
      A0PJP0

    4. XM_047427234.1 → XP_047283190.1  E3 ubiquitin ligase RNF121 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      71855935..71924512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369292.1 → XP_054225267.1  E3 ubiquitin ligase RNF121 isoform X4

    2. XM_054369291.1 → XP_054225266.1  E3 ubiquitin ligase RNF121 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_194452.1: Suppressed sequence

      Description
      NM_194452.1: This RefSeq was permanently suppressed because it was annotated with an overlapping downstream ORF when an upstream ORF existed. However, use of the upstream AUG will render this transcript susceptible to nonsense-mediated mRNA decay (NMD).

    2. NM_194453.1: Suppressed sequence

      Description
      NM_194453.1: This RefSeq was permanently suppressed because it was annotated with an overlapping downstream ORF when an upstream ORF existed. However, use of the upstream AUG will render this transcript susceptible to nonsense-mediated mRNA decay (NMD).
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H920.1 GenPept UniProtKB/Swiss-Prot:Q9H920

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