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    Gadd45gip1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 102060, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gadd45gip1provided by MGI
    Official Full Name
    growth arrest and DNA-damage-inducible, gamma interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1914947
    See related
    Ensembl:ENSMUSG00000033751 AllianceGenome:MGI:1914947
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crif1; Plinp1; MRP-L59; 2310040G17Rik
    Summary
    Located in mitochondrion. Is expressed in several structures, including brain; early conceptus; intestine epithelium; and secondary oocyte. Used to study type 2 diabetes mellitus. Orthologous to human GADD45GIP1 (GADD45G interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 129.2), ovary adult (RPKM 87.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gadd45gip1 in Genome Data Viewer
    Location:
    8 C3; 8 41.19 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85558911..85562111)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84832282..84835482)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA G430095P16 gene Neighboring gene nuclear factor I/X Neighboring gene VISTA enhancer mm21 Neighboring gene VISTA enhancer mm1615 Neighboring gene STARR-seq mESC enhancer starr_22139 Neighboring gene DAN domain family member 5, BMP antagonist Neighboring gene STARR-positive B cell enhancer ABC_E5027 Neighboring gene RIKEN cDNA 1700122E12 gene Neighboring gene STARR-positive B cell enhancer ABC_E564 Neighboring gene RAD23 homolog A, nucleotide excision repair protein Neighboring gene calreticulin Neighboring gene predicted gene 5911

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRIF1 is essential for the synthesis and insertion of oxidative phosphorylation polypeptides in the mammalian mitochondrial membrane. Kim SJ, et al. Cell Metab, 2012 Aug 8. PMID 22819524
    2. Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure. Kim YK, et al. Diabetologia, 2015 Apr. PMID 25660120
    3. Endothelial-specific Crif1 deletion induces BBB maturation and disruption via the alteration of actin dynamics by impaired mitochondrial respiration. Lee MJ, et al. J Cereb Blood Flow Metab, 2020 Jul. PMID 31987007, Free PMC Article
    4. Deficiency of Crif1 in hair follicle stem cells retards hair growth cycle in adult mice. Shin JM, et al. PLoS One, 2020. PMID 32330194, Free PMC Article
    5. Mitochondrial oxidative phosphorylation reserve is required for hormone- and PPARγ agonist-induced adipogenesis. Ryu MJ, et al. Mol Cells, 2013 Feb. PMID 23456335, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of Crif1 protects fatty acid-induced POMC neuron-like cell-line damage by increasing CPT-1 function.
      Title: Inhibition of Crif1 protects fatty acid-induced POMC neuron-like cell-line damage by increasing CPT-1 function.
    2. Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism.
      Title: Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism.
    3. CRIF1 promotes the progression of non-small-cell lung cancer by SIRT3- mediated deacetylation of PYCR1.
      Title: CRIF1 promotes the progression of non-small-cell lung cancer by SIRT3- mediated deacetylation of PYCR1.
    4. B Cell-Specific Deletion of CR6-Interacting Factor 1 Drives Lupus-like Autoimmunity by Activation of Interleukin-17, Interleukin-6, and Pathogenic Follicular Helper T Cells in a Mouse Model.
      Title: B Cell-Specific Deletion of CR6-Interacting Factor 1 Drives Lupus-like Autoimmunity by Activation of Interleukin-17, Interleukin-6, and Pathogenic Follicular Helper T Cells in a Mouse Model.
    5. Collecting Duct-Specific CR6-Interacting Factor-1-Deletion Aggravates Renal Inflammation and Fibrosis Induced by Unilateral Ureteral Obstruction.
      Title: Collecting Duct-Specific CR6-Interacting Factor-1-Deletion Aggravates Renal Inflammation and Fibrosis Induced by Unilateral Ureteral Obstruction.
    6. Mitochondrial Dysfunction in Podocytes Caused by CRIF1 Deficiency Leads to Progressive Albuminuria and Glomerular Sclerosis in Mice.
      Title: Mitochondrial Dysfunction in Podocytes Caused by CRIF1 Deficiency Leads to Progressive Albuminuria and Glomerular Sclerosis in Mice.
    7. An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models.
      Title: An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models.
    8. HFSC populations were maintained in Crif1 K15icKO mice. Results suggest that mitochondrial function in HFSCs is important for the progression of hair growth cycle, but not for maintenance of HFSCs.
      Title: Deficiency of Crif1 in hair follicle stem cells retards hair growth cycle in adult mice.
    9. To investigate the impact of loss of CRIF1 in T cells, we generated a conditional CRIF1 gene ablation model using CD4-cre transgenic mice and examined the frequency of Th17 cells and regulatory T cells.
      Title: CR6-interacting factor 1 controls autoimmune arthritis by regulation of signal transducer and activator of transcription 3 pathway and T helper type 17 cells.
    10. Crif1(beta-/-) mouse is a useful model for the study of beta cell failure caused by mitochondrial OxPhos dysfunction.
      Title: Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein mL64
    Names
    39S ribosomal protein L59, mitochondrial
    growth arrest and DNA damage-inducible proteins-interacting protein 1
    papillomavirus L2 interacting nuclear protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183358.4 → NP_899202.3  large ribosomal subunit protein mL64

      Status: VALIDATED

      Source sequence(s)
      AK002738, AK028227
      Consensus CDS
      CCDS22478.1
      UniProtKB/Swiss-Prot
      Q8BT05, Q9CR59
      Related
      ENSMUSP00000037783.6, ENSMUST00000036734.6
      Conserved Domains (1) summary
      pfam10147
      Location:42 → 211
      CR6_interact; Growth arrest and DNA-damage-inducible proteins-interacting protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      85558911..85562111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR59.1 GenPept UniProtKB/Swiss-Prot:Q9CR59

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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