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    Timm10b translocase of inner mitochondrial membrane 10B [ Mus musculus (house mouse) ]

    Gene ID: 14356, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Timm10bprovided by MGI
    Official Full Name
    translocase of inner mitochondrial membrane 10Bprovided by MGI
    Primary source
    MGI:MGI:1315196
    See related
    Ensembl:ENSMUSG00000089847 Ensembl:ENSMUSG00000110234 AllianceGenome:MGI:1315196
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fxc1; Tim9b; Tim10b
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in protein transport. Located in mitochondrion. Is expressed in several structures, including brain; brown fat; exocrine gland; genitourinary system; and thymus. Orthologous to human TIMM10B (translocase of inner mitochondrial membrane 10B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 28.9), duodenum adult (RPKM 21.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Timm10b in Genome Data Viewer
    Location:
    7 E3; 7 55.93 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105289652..105304955)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105640445..105655748)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E9700 Neighboring gene ARF interacting protein 2 Neighboring gene predicted gene, 22504 Neighboring gene dynein heavy chain domain 1 Neighboring gene mitochondrial ribosomal protein S36, pseudogene 2 Neighboring gene ribosomal RNA processing 8 Neighboring gene integrin linked kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning of a novel cDNA expressed during the early stages of fracture healing. Hadjiargyrou M, et al. Biochem Biophys Res Commun, 1998 Aug 28. PMID 9731230
    2. The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins. Jin H, et al. Genomics, 1999 Nov 1. PMID 10552927
    3. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. Bauer MF, et al. FEBS Lett, 1999 Dec 24. PMID 10611480
    4. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TIM22 mitochondrial import inner membrane insertion complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial intermembrane space protein transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial intermembrane space protein transporter complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim10 B
    Names
    Fracture Callus 1
    fractured callus 1
    fractured callus expressed transcript 1
    mitochondrial import inner membrane translocase subunit Tim9 B
    small zinc finger-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360052.1 → NP_001346981.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC125227
      Consensus CDS
      CCDS90303.1
      UniProtKB/TrEMBL
      D3YVK4
      Related
      ENSMUSP00000102398.2, ENSMUST00000106786.8
      Conserved Domains (1) summary
      pfam02953
      Location:9 → 64
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    2. NM_001360053.1 → NP_001346982.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform b

      Status: VALIDATED

      Source sequence(s)
      AC125227, BY707453
      UniProtKB/TrEMBL
      D3YVK5
      Conserved Domains (1) summary
      pfam02953
      Location:9 → 67
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    3. NM_001360054.1 → NP_001346983.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform c

      Status: VALIDATED

      Source sequence(s)
      AC125227, AV583975
      Consensus CDS
      CCDS90304.1
      UniProtKB/TrEMBL
      D3YVK6
      Related
      ENSMUSP00000102396.2, ENSMUST00000106784.2

    4. NM_001360055.1 → NP_001346984.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform d.
      Source sequence(s)
      AC125227
      Consensus CDS
      CCDS21657.1
      UniProtKB/Swiss-Prot
      Q545D2, Q9DCB5, Q9WV96
      UniProtKB/TrEMBL
      D3YVK5
      Related
      ENSMUSP00000102392.2, ENSMUST00000106780.2
      Conserved Domains (1) summary
      pfam02953
      Location:9 → 64
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    5. NM_001360056.1 → NP_001346985.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform d.
      Source sequence(s)
      AC125227, AK010994
      Consensus CDS
      CCDS21657.1
      UniProtKB/Swiss-Prot
      Q545D2, Q9DCB5, Q9WV96
      UniProtKB/TrEMBL
      D3YVK5
      Related
      ENSMUSP00000057061.4, ENSMUST00000058333.10
      Conserved Domains (1) summary
      pfam02953
      Location:9 → 64
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    6. NM_001360058.1 → NP_001346987.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform e

      Status: VALIDATED

      Source sequence(s)
      AC125227, CK622744
      Consensus CDS
      CCDS90302.1
      UniProtKB/TrEMBL
      A0A1B0GSU2, D3YVK5
      Related
      ENSMUSP00000148071.2, ENSMUST00000210350.2
      Conserved Domains (1) summary
      pfam02953
      Location:9 → 64
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    7. NM_001360059.1 → NP_001346988.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform f

      Status: VALIDATED

      Source sequence(s)
      AC125227
      UniProtKB/TrEMBL
      D3YVK5
      Conserved Domains (1) summary
      pfam02953
      Location:9 → 64
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    8. NM_001360060.1 → NP_001346989.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform g

      Status: VALIDATED

      Source sequence(s)
      AC125227, AK003421
      Conserved Domains (1) summary
      pfam02953
      Location:1 → 44
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    9. NM_001360061.1 → NP_001346990.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform h

      Status: VALIDATED

      Source sequence(s)
      AC125227
      Consensus CDS
      CCDS90305.1
      UniProtKB/TrEMBL
      A0A1B0GRJ5, D6RG99
      Related
      ENSMUSP00000147720.2, ENSMUST00000209588.2

    10. NM_019502.3 → NP_062375.1  mitochondrial import inner membrane translocase subunit Tim10 B isoform d

      See identical proteins and their annotated locations for NP_062375.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform d.
      Source sequence(s)
      AC125227
      Consensus CDS
      CCDS21657.1
      UniProtKB/Swiss-Prot
      Q545D2, Q9DCB5, Q9WV96
      UniProtKB/TrEMBL
      D3YVK5
      Related
      ENSMUSP00000102395.2, ENSMUST00000106783.8
      Conserved Domains (1) summary
      pfam02953
      Location:9 → 64
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    RNA

    1. NR_153392.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125227

    2. NR_153393.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125227, BY233702

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      105289652..105304955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WV96.1 GenPept UniProtKB/Swiss-Prot:Q9WV96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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