Farsa phenylalanyl-tRNA synthetase, alpha subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Farsaprovided by MGI
Official Full Name: phenylalanyl-tRNA synthetase, alpha subunitprovided by MGI
Primary source: MGI:MGI:1913840
See related: Ensembl:ENSMUSG00000003808 AllianceGenome:MGI:1913840
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: pheRS; Farsla; 0610012A19Rik
Summary: Predicted to enable magnesium ion binding activity and phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and protein heterotetramerization. Predicted to be part of phenylalanine-tRNA ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and respiratory system. Orthologous to human FARSA (phenylalanyl-tRNA synthetase subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14.5 (RPKM 34.6), whole brain E14.5 (RPKM 32.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 41.23 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (85583597..85595886)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84856969..84869257)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

NoName (e-PCR)
- UniSTS:235950

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables phenylalanine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phenylalanine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables phenylalanine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phenylalanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phenylalanyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
involved_in phenylalanyl-tRNA aminoacylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein heterotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein heterotetramerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of phenylalanine-tRNA ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phenylalanine-tRNA ligase complex	ISO Inferred from Sequence Orthology more info
part_of phenylalanine-tRNA ligase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phenylalanine--tRNA ligase alpha subunit

Names: phenylalanine--tRNA ligase alpha chain; phenylalanine-tRNA synthetase-like, alpha subunit; phenylalanyl-tRNA synthetase alpha chain

NP_079924.2

EC 6.1.1.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025648.3 → NP_079924.2 phenylalanine--tRNA ligase alpha subunit

Status: VALIDATED

Source sequence(s)

AK002577, AK031697, BB853717, BP754226

Consensus CDS

CCDS22480.2

UniProtKB/Swiss-Prot

Q3U3Q9, Q8C0C7, Q91WR4, Q922S1

UniProtKB/TrEMBL

E9PWY9

Related

ENSMUSP00000003906.7, ENSMUST00000003906.13

Conserved Domains (2) summary

PLN02853
Location:22 → 497

PLN02853; Probable phenylalanyl-tRNA synthetase alpha chain

pfam01409
Location:209 → 482

tRNA-synt_2d; tRNA synthetases class II core domain (F)