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    Ankrd54 ankyrin repeat domain 54 [ Mus musculus (house mouse) ]

    Gene ID: 223690, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ankrd54provided by MGI
    Official Full Name
    ankyrin repeat domain 54provided by MGI
    Primary source
    MGI:MGI:2444209
    See related
    Ensembl:ENSMUSG00000033055 AllianceGenome:MGI:2444209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Liar; EST475269; EST1068184; C730048E16Rik
    Summary
    Enables protein kinase regulator activity. Acts upstream of or within several processes, including nucleocytoplasmic transport; positive regulation of erythrocyte differentiation; and regulation of protein kinase activity. Located in cytoplasm; midbody; and nucleus. Is expressed in several structures, including branchial arch; central nervous system; gut; immune system; and limb bud. Orthologous to human ANKRD54 (ankyrin repeat domain 54). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 104.4), duodenum adult (RPKM 40.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd54 in Genome Data Viewer
    Location:
    15 E1; 15 37.7 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78937294..78947129, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79053094..79062927, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase) Neighboring gene galanin receptor 3 Neighboring gene predicted gene 3924 Neighboring gene STARR-positive B cell enhancer ABC_E1482 Neighboring gene STARR-seq mESC enhancer starr_39166 Neighboring gene eukaryotic translation initiation factor 3, subunit L Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing -like 1 Neighboring gene RIKEN cDNA 1700088E04 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54). Gustafsson MO, et al. Mol Cell Biol, 2012 Jul. PMID 22527282, Free PMC Article
    2. Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation. Samuels AL, et al. Blood, 2009 Apr 16. PMID 19064729
    3. Comparative analyses of the Dominant megacolon-SOX10 genomic interval in mouse and human. Southard-Smith EM, et al. Mamm Genome, 1999 Jul. PMID 10384052
    4. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
    5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Liar is the first protein identified that specifically influences the nucleocytoplasmic shuttling of Btk and Txk and belongs to a rare group of known proteins carrying out this activity in a Crm1-dependent manner.
      Title: Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54).
    2. Liar is a novel Lyn-interacting molecule that plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.
      Title: Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation.
    3. Ankrd54 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
      Title: Tissue expression patterns identify mouse cilia genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25673

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within nucleocytoplasmic transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 54
    Names
    lyn-interacting ankyrin repeat protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378988.1 → NP_001365917.1  ankyrin repeat domain-containing protein 54 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589670
      Conserved Domains (2) summary
      sd00045
      Location:141 → 172
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:117 → 205
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001378989.1 → NP_001365918.1  ankyrin repeat domain-containing protein 54 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL589670
      Conserved Domains (2) summary
      sd00045
      Location:141 → 172
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:117 → 205
      Ank_2; Ankyrin repeats (3 copies)

    3. NM_001378990.1 → NP_001365919.1  ankyrin repeat domain-containing protein 54 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL589670
      Conserved Domains (2) summary
      sd00045
      Location:141 → 172
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:117 → 198
      Ank_2; Ankyrin repeats (3 copies)

    4. NM_144849.1 → NP_659098.1  ankyrin repeat domain-containing protein 54 isoform 1

      See identical proteins and their annotated locations for NP_659098.1

      Status: VALIDATED

      Source sequence(s)
      BC014743
      Consensus CDS
      CCDS37139.1
      UniProtKB/Swiss-Prot
      Q3UPC5, Q3UZL7, Q91WK7
      UniProtKB/TrEMBL
      A7YB12
      Related
      ENSMUSP00000047042.5, ENSMUST00000040676.11
      Conserved Domains (3) summary
      cd00204
      Location:117 → 231
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:117 → 205
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:141 → 172
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78937294..78947129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245584.4 → XP_011243886.1  ankyrin repeat domain-containing protein 54 isoform X2

      Conserved Domains (2) summary
      sd00045
      Location:141 → 172
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:117 → 198
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_036159352.1 → XP_036015245.1  ankyrin repeat domain-containing protein 54 isoform X3

      Conserved Domains (2) summary
      sd00045
      Location:141 → 172
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:117 → 198
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_030248498.2 → XP_030104358.1  ankyrin repeat domain-containing protein 54 isoform X1

      Conserved Domains (2) summary
      sd00045
      Location:141 → 172
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:117 → 205
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WK7.1 GenPept UniProtKB/Swiss-Prot:Q91WK7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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