Slc38a1 solute carrier family 38, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc38a1provided by MGI
Official Full Name: solute carrier family 38, member 1provided by MGI
Primary source: MGI:MGI:2145895
See related: Ensembl:ENSMUSG00000023169 AllianceGenome:MGI:2145895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NAT2; SNAT1; Gm32457
Summary: Enables L-glutamine transmembrane transporter activity. Involved in gamma-aminobutyric acid biosynthetic process; glutamine transport; and modulation of chemical synaptic transmission. Located in axon and basolateral plasma membrane. Is expressed in several structures, including alimentary system; early embryo; extraembryonic component; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SLC38A1 (solute carrier family 38 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cerebellum adult (RPKM 28.9), placenta adult (RPKM 22.1) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15; 15 F1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (96469299..96541396, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (96571418..96643438, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Slc38a1 Conveys Astroglia-Derived Glutamine into GABAergic Interneurons for Neurotransmitter GABA Synthesis.
Title: Slc38a1 Conveys Astroglia-Derived Glutamine into GABAergic Interneurons for Neurotransmitter GABA Synthesis.
The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity.
Title: The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity.
interacts with voltage-gated CaV2.2 calcium channels
Title: Four novel interaction partners demonstrate diverse modulatory effects on voltage-gated Ca(V)2.2 Ca(2+) channels.
These results demonstrate that SNAT1 promoted ischemic brain damage via mTOR-autophagy system.
Title: Inhibition of the glutamine transporter SNAT1 confers neuroprotection in mice by modulating the mTOR-autophagy system.
The amino acid transporter gene Slc38a1 appears to be a novel gene responsive to hypoxic stress in a manner dependent on HIF-1alpha in brown adipocytes. In addition to in vitro studies, we showed that the Slc38a1 expression was enhanced in the brown adipose tissue of obesity model mice in vivo.
Title: Hypoxic Stress Upregulates the Expression of Slc38a1 in Brown Adipocytes via Hypoxia-Inducible Factor-1α.
Hence, pro-degenerative MAPK signaling functions upstream of SARM1 by limiting the levels of the essential axonal survival factor NMNAT2 to promote injury-dependent SARM1 activation.
Title: MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2.
Changes in transporter expression likely reflect different amino acid requirements during development. Findings include the differential expression of SNAT1 in the inner and outer cells of the compacted morula and nuclear localisation of SNAT2 in the trophectoderm and placental lineages.
Title: Regulation of amino acid transporters in pluripotent cell populations in the embryo and in culture; novel roles for sodium-coupled neutral amino acid transporters.
Overexpression of X-box binding protein-1 led to a marked increase in luciferase activity in P19 cells transfected with the Slc38a1 reporter plasmid. These results suggest that theanine accelerates cellular proliferation and subsequent neuronal specification through a mechanism relevant to upregulation of Slc38a1 gene in undifferentiated neural progenitor cells
Title: Upregulation of Slc38a1 Gene Along with Promotion of Neurosphere Growth and Subsequent Neuronal Specification in Undifferentiated Neural Progenitor Cells Exposed to Theanine.
We found that MeCP2 acts as a microglia-specific transcriptional repressor of
Title: Dysregulation of glutamine transporter SNAT1 in Rett syndrome microglia: a mechanism for mitochondrial dysfunction and neurotoxicity.
GlnT would promote both proliferation and neuronal differentiation through a mechanism relevant to the upregulation of particular proneural genes in undifferentiated P19 cells.
Title: Promotion of both proliferation and neuronal differentiation in pluripotent P19 cells with stable overexpression of the glutamine transporter slc38a1.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc38a1 (e-PCR), detects polymorphism
- UniSTS:547338

RH125894 (e-PCR)
- UniSTS:162620

NoName (e-PCR)
- UniSTS:237388

AU015942 (e-PCR)
- UniSTS:180823

RH125354 (e-PCR)
- UniSTS:162176

RH124900 (e-PCR)
- UniSTS:161722

RH124660 (e-PCR)
- UniSTS:161482

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables alanine:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables alanine:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables amino acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycine:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables glycine:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables neutral L-amino acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables proline:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables proline:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-alpha-amino acid transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in L-alpha-amino acid transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in alanine transport	IEA Inferred from Electronic Annotation more info
involved_in amino acid import	ISO Inferred from Sequence Orthology more info
involved_in amino acid import	ISS Inferred from Sequence or Structural Similarity more info
involved_in amino acid transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutamine transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycine transport	IEA Inferred from Electronic Annotation more info
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of L-glutamine import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of L-glutamine import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium-coupled neutral amino acid symporter 1

Names: MNat2; N-system amino acid transporter 2; amino acid transporter A1; sodium-coupled neutral amino acid transporter 1; system A amino acid transporter 1; system N amino acid transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166456.1 → NP_001159928.1 sodium-coupled neutral amino acid symporter 1

See identical proteins and their annotated locations for NP_001159928.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.

Source sequence(s)

AC109201, AC123606, AK035098, AK082683

Consensus CDS

CCDS27777.1

UniProtKB/Swiss-Prot

Q3TNM1, Q3TQ53, Q6NXZ2, Q8BHI3, Q8BXE2, Q8K2P7, Q99PR1

Related

ENSMUSP00000085801.6, ENSMUST00000088454.13

Conserved Domains (1) summary

cl00456
Location:69 → 472

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
NM_001166458.1 → NP_001159930.1 sodium-coupled neutral amino acid symporter 1

See identical proteins and their annotated locations for NP_001159930.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.

Source sequence(s)

AC123606, AK081724

Consensus CDS

CCDS27777.1

UniProtKB/Swiss-Prot

Q3TNM1, Q3TQ53, Q6NXZ2, Q8BHI3, Q8BXE2, Q8K2P7, Q99PR1

Related

ENSMUSP00000085799.5, ENSMUST00000088452.11

Conserved Domains (1) summary

cl00456
Location:69 → 472

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
NM_134086.4 → NP_598847.2 sodium-coupled neutral amino acid symporter 1

See identical proteins and their annotated locations for NP_598847.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.

Source sequence(s)

AC123606, AK034130, AK165188

Consensus CDS

CCDS27777.1

UniProtKB/Swiss-Prot

Q3TNM1, Q3TQ53, Q6NXZ2, Q8BHI3, Q8BXE2, Q8K2P7, Q99PR1

Related

ENSMUSP00000097833.3, ENSMUST00000100262.4

Conserved Domains (1) summary

cl00456
Location:69 → 472

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

96469299..96541396 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159052.1 → XP_036014945.1 sodium-coupled neutral amino acid symporter 1 isoform X1

UniProtKB/Swiss-Prot

Q3TNM1, Q3TQ53, Q6NXZ2, Q8BHI3, Q8BXE2, Q8K2P7, Q99PR1

Conserved Domains (1) summary

cl00456
Location:69 → 472

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_030248259.2 → XP_030104119.1 sodium-coupled neutral amino acid symporter 1 isoform X1

UniProtKB/Swiss-Prot

Q3TNM1, Q3TQ53, Q6NXZ2, Q8BHI3, Q8BXE2, Q8K2P7, Q99PR1

Conserved Domains (1) summary

cl00456
Location:69 → 472

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_030248257.2 → XP_030104117.1 sodium-coupled neutral amino acid symporter 1 isoform X1

UniProtKB/Swiss-Prot

Q3TNM1, Q3TQ53, Q6NXZ2, Q8BHI3, Q8BXE2, Q8K2P7, Q99PR1

Conserved Domains (1) summary

cl00456
Location:69 → 472

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_030248258.2 → XP_030104118.1 sodium-coupled neutral amino acid symporter 1 isoform X1

UniProtKB/Swiss-Prot

Q3TNM1, Q3TQ53, Q6NXZ2, Q8BHI3, Q8BXE2, Q8K2P7, Q99PR1

Conserved Domains (1) summary

cl00456
Location:69 → 472

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006520235.5 → XP_006520298.1 sodium-coupled neutral amino acid symporter 1 isoform X1

See identical proteins and their annotated locations for XP_006520298.1

UniProtKB/Swiss-Prot

Q3TNM1, Q3TQ53, Q6NXZ2, Q8BHI3, Q8BXE2, Q8K2P7, Q99PR1

Conserved Domains (1) summary

cl00456
Location:69 → 472

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain