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    thiP thiamine ABC transporter membrane subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944784, updated on 3-Dec-2024

    Summary

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    Official Symbol
    thiP
    Official Full Name
    thiamine ABC transporter membrane subunit
    Primary source
    ECOCYC:EG11573
    Locus tag
    b0067
    See related
    ASAP:ABE-0000246
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0068; sfuB; yabK
    Summary
    [More information is available at EcoGene: EG11573]. The ABC transporter ThiBPQ was functionally characterized in Salmonella typhimurium where it is required for the uptake of thiamine and thiamine pyrophosphate . [More information is available at EcoCyc: EG11573].
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    Genomic context

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    Sequence:
    NC_000913.3 (72911..74521, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator AraC Neighboring gene DedA family protein YabI Neighboring gene thiamine ABC transporter ATP binding subunit Neighboring gene thiamine ABC transporter periplasmic binding protein Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator SgrR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thiamine transport in Escherichia coli Crookes. Leach FR, et al. Methods Enzymol, 1979. PMID 374984
    2. Inhibition by thiamine phosphates of thiamine uptake in Escherichia coli. Matsuura A, et al. J Vitaminol (Kyoto), 1972 Mar 10. PMID 4556265
    3. Biosynthetic pathway of thiamine pyrophosphate: a special reference to the thiamine monophosphate-requiring mutant and the thiamine pyrophosphate-requiring mutant of Escherichia coli. Nakayama H, et al. J Bacteriol, 1972 Dec. PMID 4565529, Free PMC Article
    4. Thiamine uptake in Escherichia coli. I. General properties of thiamine uptake system in Escherichia coli. Kawasaki T, et al. Arch Biochem Biophys, 1969 Apr. PMID 4889357
    5. Thiamine transport in Escherichia coli: the mechanism of inhibition by the sulfhydryl-specific modifier N-ethylmaleimide. Hollenbach AD, et al. Biochim Biophys Acta, 2002 Aug 31. PMID 12175925

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables thiamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within thiamine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in thiamine transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in thiamine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thiamine ABC transporter membrane subunit
    NP_414609.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      72911..74521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414609.1 thiamine ABC transporter membrane subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414609.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7F9E0
      Conserved Domains (1) summary
      PRK09433
      Location:11 → 535
      thiP; thiamine transporter membrane protein; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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