leuA 2-isopropylmalate synthase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: leuA
Official Full Name: 2-isopropylmalate synthase
Primary source: ECOCYC:EG11226
Locus tag: b0074
See related: ASAP:ABE-0000267
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0076
Summary: 2-isopropylmalate synthase (LeuA) carries out the first step in leucine biosynthesis. [More information is available at EcoCyc: EG11226].
NEW: Try the new Gene table
Try the new Transcript table

NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

N-terminus verified by Edman degradation on mature peptide
Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 2-isopropylmalate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2-isopropylmalate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables 2-isopropylmalate synthase activity	IEA Inferred from Electronic Annotation more info
enables 2-isopropylmalate synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acetyl-CoA C-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-leucine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-leucine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within L-leucine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_414616.1

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain