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    pdhR DNA-binding transcriptional dual regulator PdhR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944827, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pdhR
    Official Full Name
    DNA-binding transcriptional dual regulator PdhR
    Primary source
    ECOCYC:EG11088
    Locus tag
    b0113
    See related
    ASAP:ABE-0000394
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    aceC; ECK0112; genA; yacB
    Summary
    The N-terminus of overexpressed PdhR has been determined (Quail and Guest, 1995), indicating that the initial Met is removed. however, the native pdhR RBS was not used, so PdhR is not in the Verified Set, although this is probably the correct start. [More information is available at EcoGene: EG11088]. PdhR, "pyruvate dehydrogenase complex regulator," regulates genes involved in the pyruvate dehydrogenase complex . [More information is available at EcoCyc: EG11088].
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    Genomic context

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    Sequence:
    NC_000913.3 (122092..122856)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 1,6-anhydro-N-acetylmuramoyl-L-alanine amidase Neighboring gene protein AmpE Neighboring gene aromatic amino acid:H(+) symporter AroP Neighboring gene pyruvate dehydrogenase E1 component Neighboring gene pyruvate dehydrogenase, E2 subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification, characterization and mode of action of PdhR, the transcriptional repressor of the pdhR-aceEF-lpd operon of Escherichia coli. Quail MA, et al. Mol Microbiol, 1995 Feb. PMID 7783622
    2. Expanded roles of pyruvate-sensing PdhR in transcription regulation of the Escherichia coli K-12 genome: fatty acid catabolism and cell motility. Anzai T, et al. Microb Genom, 2020 Oct. PMID 32975502, Free PMC Article
    3. PdhR, the pyruvate dehydrogenase repressor, does not regulate lipoic acid synthesis. Feng Y, et al. Res Microbiol, 2014 Jul-Aug. PMID 24816490, Free PMC Article
    4. The pyruvate dehydrogenase complex of Escherichia coli K12. Nucleotide sequence encoding the pyruvate dehydrogenase component. Stephens PE, et al. Eur J Biochem, 1983 Jun 1. PMID 6343085
    5. The pdhR-aceEF-lpd operon of Escherichia coli expresses the pyruvate dehydrogenase complex. Quail MA, et al. Mol Microbiol, 1994 Apr. PMID 8057842

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expanded roles of pyruvate-sensing PdhR in transcription regulation of the Escherichia coli K-12 genome: fatty acid catabolism and cell motility.
      Title: Expanded roles of pyruvate-sensing PdhR in transcription regulation of the Escherichia coli K-12 genome: fatty acid catabolism and cell motility.
    2. These data show that PdhR plays no physiological role in regulation of lipA expression.
      Title: PdhR, the pyruvate dehydrogenase repressor, does not regulate lipoic acid synthesis.
    3. Study suggests that PdhR is a master regulator for controlling the formation of not only the PDH complex but also the respiratory electron transport system.
      Title: PdhR (pyruvate dehydrogenase complex regulator) controls the respiratory electron transport system in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator PdhR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      122092..122856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414655.1 DNA-binding transcriptional dual regulator PdhR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414655.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A826J305
      Conserved Domains (1) summary
      PRK09464
      Location:1 → 234
      pdhR; pyruvate dehydrogenase complex transcriptional repressor PdhR
    Nucleotide Protein
    Heading Accession and Version

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