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    hscC chaperone protein HscC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945218, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hscC
    Official Full Name
    chaperone protein HscC
    Primary source
    ECOCYC:G6357
    Locus tag
    b0650
    See related
    ASAP:ABE-0002225
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0643; ybeW
    Summary
    dnaK, hscA, hscC and yegD are paralogs. [More information is available at EcoGene: EG13653]. HscC (Hsc62) is an Escherichia coli-specific member of the Hsc66 subfamily of Hsp70-family chaperones . [More information is available at EcoCyc: G6357].
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    Genomic context

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    Sequence:
    NC_000913.3 (681723..683393, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Sel1 repeat-containing protein YbeT Neighboring gene DUF1266 domain-containing protein YbeU Neighboring gene co-chaperone DjlC Neighboring gene pyrimidine-specific ribonucleoside hydrolase RihA Neighboring gene glutamate/aspartate ABC transporter ATP binding subunit Neighboring gene glutamate/aspartate ABC transporter membrane subunit GltK

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic analysis of the third hsp70 homolog in Escherichia coli; a novel member of the Hsc66 subfamily and its possible co-chaperone. Itoh T, et al. DNA Res, 1999 Oct 29. PMID 10574456
    2. Hsc62, Hsc56, and GrpE, the third Hsp70 chaperone system of Escherichia coli. Yoshimune K, et al. Biochem Biophys Res Commun, 2002 May 24. PMID 12054669
    3. The Hsp70 chaperone machines of Escherichia coli: a paradigm for the repartition of chaperone functions. Genevaux P, et al. Mol Microbiol, 2007 Nov. PMID 17919282
    4. Not all J domains are created equal: implications for the specificity of Hsp40-Hsp70 interactions. Hennessy F, et al. Protein Sci, 2005 Jul. PMID 15987899, Free PMC Article
    5. The ATPase domain of HscC (DnaK homolog) is essential for interfering sigma70 activity in E. coli. Arifuzzaman M, et al. FEMS Microbiol Lett, 2004 Jan 15. PMID 14734171

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chaperone protein HscC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      681723..683393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415183.1 chaperone protein HscC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415183.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377DWA4
      Conserved Domains (1) summary
      cd10235
      Location:8 → 343
      HscC_like_NBD; Nucleotide-binding domain of Escherichia coli HscC and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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