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    rhtA L-threonine/L-homoserine exporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947045, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rhtA
    Official Full Name
    L-threonine/L-homoserine exporter
    Primary source
    ECOCYC:EG12134
    Locus tag
    b0813
    See related
    ASAP:ABE-0002779
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0802; ybiF
    Summary
    RhtA belongs to the EamA/RhaT transporter family, DMT superfamily. [More information is available at EcoGene: EG12134]. RhtA is a threonine/homoserine exporter in the Drug/Metabolite Transporter superfamily (TC: [More information is available at EcoCyc: EG12134].
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    Genomic context

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    Sequence:
    NC_000913.3 (849210..850097, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-glutamine ABC transporter periplasmic binding protein Neighboring gene DNA protection during starvation protein Neighboring gene protein YliM Neighboring gene outer membrane protein X

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the new gene rhtA involved in threonine and homoserine efflux in Escherichia coli. Livshits VA, et al. Res Microbiol, 2003 Mar. PMID 12648727
    2. Characterization of the sigma 38-dependent expression of a core Escherichia coli starvation gene, pexB. Lomovskaya OL, et al. J Bacteriol, 1994 Jul. PMID 8021175, Free PMC Article
    3. Identification of co-regulated genes through Bayesian clustering of predicted regulatory binding sites. Qin ZS, et al. Nat Biotechnol, 2003 Apr. PMID 12627170
    4. Factors influencing the identification of transcription factor binding sites by cross-species comparison. McCue LA, et al. Genome Res, 2002 Oct. PMID 12368244, Free PMC Article
    5. TCDB: the Transporter Classification Database for membrane transport protein analyses and information. Saier MH Jr, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381841, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables homoserine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables homoserine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables secondary active transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables threonine efflux transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables threonine efflux transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables threonine efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within homoserine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within homoserine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within threonine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within threonine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-threonine/L-homoserine exporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      849210..850097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415334.1 L-threonine/L-homoserine exporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415334.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5D8MQG6
      Conserved Domains (1) summary
      PRK10532
      Location:1 → 293
      PRK10532; threonine and homoserine efflux system; Provisional
    Nucleotide Protein
    Heading Accession and Version

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