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    serS serine--tRNA ligase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945506, updated on 3-Dec-2024

    Summary

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    Official Symbol
    serS
    Official Full Name
    serine--tRNA ligase
    Primary source
    ECOCYC:EG10947
    Locus tag
    b0893
    See related
    ASAP:ABE-0003038
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0884
    Summary
    Seryl-tRNA synthetase (SerRS) is a member of the family of aminoacyl-tRNA synthetases, which interpret the genetic code by covalently linking amino acids to their specific tRNA molecules. [More information is available at EcoCyc: EG10947].
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    Genomic context

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    Sequence:
    NC_000913.3 (939428..940720)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene outer membrane lipoprotein carrier protein Neighboring gene replication-associated recombination protein A Neighboring gene dimethyl sulfoxide reductase subunit A Neighboring gene dimethyl sulfoxide reductase subunit B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Variant minihelix RNAs reveal sequence-specific recognition of the helical tRNA(Ser) acceptor stem by E.coli seryl-tRNA synthetase. Saks ME, et al. EMBO J, 1996 Jun 3. PMID 8654382, Free PMC Article
    2. Discrimination among E. coli tRNAs with a long variable arm. Asahara H, et al. Nucleic Acids Symp Ser, 1993. PMID 7504246
    3. tRNA recognition and evolution of determinants in seryl-tRNA synthesis. Lenhard B, et al. Nucleic Acids Res, 1999 Feb 1. PMID 9889265, Free PMC Article
    4. Purification and properties of seryl transfer ribonucleic acid synthetase from Escherichia coli. Katze JR, et al. J Biol Chem, 1970 Mar 10. PMID 4906848
    5. Selective inhibition of divergent seryl-tRNA synthetases by serine analogues. Ahel D, et al. FEBS Lett, 2005 Aug 15. PMID 16054140

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within selenocysteine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in selenocysteine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within seryl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in seryl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in seryl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine--tRNA ligase
    NP_415413.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      939428..940720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415413.1 serine--tRNA ligase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415413.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377E7J2, A0A5B9AND2
      Conserved Domains (1) summary
      PRK05431
      Location:1 → 430
      PRK05431; seryl-tRNA synthetase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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