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    pgaD poly-N-acetyl-D-glucosamine synthase subunit PgaD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947503, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pgaD
    Official Full Name
    poly-N-acetyl-D-glucosamine synthase subunit PgaD
    Primary source
    ECOCYC:G6528
    Locus tag
    b1021
    See related
    ASAP:ABE-0003460
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1011; hmsS; ycdP
    Summary
    PgaD complements a mutation in the homologous Y. pestis hemin storage gene hmsS. [More information is available at EcoGene: EG13862]. The PgaD protein is involved in biofilm formation. [More information is available at EcoCyc: G6528].
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    Genomic context

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    Sequence:
    NC_000913.3 (1086106..1086519, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene heme-containing peroxidase/deferrochelatase Neighboring gene ATP-binding protein PhoH Neighboring gene poly-N-acetyl-D-glucosamine synthase subunit PgaC Neighboring gene poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase and beta-1,6 glycoside hydrolase Neighboring gene partially deacetylated poly-beta-1,6-N-acetyl-D-glucosamine export outer membrane porin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein-protein interaction. Steiner S, et al. EMBO J, 2013 Feb 6. PMID 23202856, Free PMC Article
    2. Depolymerization of beta-1,6-N-acetyl-D-glucosamine disrupts the integrity of diverse bacterial biofilms. Itoh Y, et al. J Bacteriol, 2005 Jan. PMID 15601723, Free PMC Article
    3. HmsT, a protein essential for expression of the haemin storage (Hms+) phenotype of Yersinia pestis. Jones HA, et al. Microbiology (Reading), 1999 Aug. PMID 10463178
    4. Effect of growth conditions on poly-N-acetylglucosamine expression and biofilm formation in Escherichia coli. Cerca N, et al. FEMS Microbiol Lett, 2008 Jun. PMID 18445167
    5. Spatial periodicity of Escherichia coli K-12 biofilm microstructure initiates during a reversible, polar attachment phase of development and requires the polysaccharide adhesin PGA. Agladze K, et al. J Bacteriol, 2005 Dec. PMID 16321928, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion involved in biofilm formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in cell adhesion involved in biofilm formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cell adhesion involved in biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell adhesion involved in single-species biofilm formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    poly-N-acetyl-D-glucosamine synthase subunit PgaD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1086106..1086519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415540.1 poly-N-acetyl-D-glucosamine synthase subunit PgaD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415540.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A792HNV3
      Conserved Domains (1) summary
      PRK14585
      Location:1 → 137
      pgaD; putative PGA biosynthesis protein; Provisional
    Nucleotide Protein
    Heading Accession and Version

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