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    chaA Na(+)/K(+):H(+) antiporter ChaA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945790, updated on 3-Dec-2024

    Summary

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    Official Symbol
    chaA
    Official Full Name
    Na(+)/K(+):H(+) antiporter ChaA
    Primary source
    ECOCYC:EG11753
    Locus tag
    b1216
    See related
    ASAP:ABE-0004082
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1210
    Summary
    ChaA is a calcium ion: proton antiporter that is a member of the Calcium: [More information is available at EcoCyc: EG11753].
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    Genomic context

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    Sequence:
    NC_000913.3 (1270749..1271849, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene small toxic polypeptide LdrC Neighboring gene ncRNA Neighboring gene putative cation transport regulator ChaB Neighboring gene glutathione-specific gamma-glutamylcyclotransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. pH and monovalent cations regulate cytosolic free Ca(2+) in E. coli. Naseem R, et al. Biochim Biophys Acta, 2008 Jun. PMID 18342619
    2. Identification of three distinct phylogenetic groups of CAX cation/proton antiporters. Shigaki T, et al. J Mol Evol, 2006 Dec. PMID 17086450
    3. Fermenting Escherichia coli is able to grow in media of high osmolarity, but is sensitive to the presence of sodium ion. Trchounian A, et al. Curr Microbiol, 1999 Aug. PMID 10398838
    4. Escherichia coli is able to grow with negligible sodium ion extrusion activity at alkaline pH. Ohyama T, et al. J Bacteriol, 1992 Dec. PMID 1332943, Free PMC Article
    5. Physiological role of the chaA gene in sodium and calcium circulations at a high pH in Escherichia coli. Ohyama T, et al. J Bacteriol, 1994 Jul. PMID 8021217, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to alkaline pH IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Na(+)/K(+):H(+) antiporter ChaA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1270749..1271849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415734.1 Na(+)/K(+):H(+) antiporter ChaA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415734.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9WWN6
      Conserved Domains (1) summary
      PRK10599
      Location:1 → 366
      PRK10599; sodium-potassium/proton antiporter ChaA
    Nucleotide Protein
    Heading Accession and Version

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