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    marR DNA-binding transcriptional repressor MarR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945825, updated on 3-Dec-2024

    Summary

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    Official Symbol
    marR
    Official Full Name
    DNA-binding transcriptional repressor MarR
    Primary source
    ECOCYC:EG11435
    Locus tag
    b1530
    See related
    ASAP:ABE-0005110
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cfxB; ECK1523; inaR; soxQ
    Summary
    Rob regulon. [More information is available at EcoGene: EG11435]. MarR, "multiple antibiotic resistance," is a transcriptional repressor that controls genes involved in multiple antibiotic resistance and susceptibility . [More information is available at EcoCyc: EG11435].
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    Genomic context

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    Sequence:
    NC_000913.3 (1619120..1619554)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-arabinose exporter Neighboring gene inner membrane protein MarC Neighboring gene DNA-binding transcriptional dual regulator MarA Neighboring gene multiple antibiotic resistance protein MarB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli. Praski Alzrigat L, et al. J Antimicrob Chemother, 2017 Nov 1. PMID 28962020, Free PMC Article
    2. Mutational analysis of MarR, the negative regulator of marRAB expression in Escherichia coli, suggests the presence of two regions required for DNA binding. Alekshun MN, et al. Mol Microbiol, 2000 Mar. PMID 10760140
    3. Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli. Kern WV, et al. Antimicrob Agents Chemother, 2000 Apr. PMID 10722475, Free PMC Article
    4. A C-terminal 18 amino acid deletion in MarR in a clinical isolate of Escherichia coli reduces MarR binding properties and increases the MIC of ciprofloxacin. Notka F, et al. J Antimicrob Chemother, 2002 Jan. PMID 11751765
    5. Structural mechanisms of multidrug recognition and regulation by bacterial multidrug transcription factors. Schumacher MA, et al. Mol Microbiol, 2002 Aug. PMID 12180910

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in marR selected in ciprofloxacin-resistant clinical isolates are strongly biased against inactivating mutations. Selection favours mutant alleles that have the lowest fitness costs, even though these cause only modest reductions in drug susceptibility.
      Title: Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli.
    2. These findings indicate, as for the MarR homologue MTH313, the presence of a ligand binding pocket located between the dimerization and DNA binding domains.
      Title: Mutational analysis of the multiple-antibiotic resistance regulator MarR reveals a ligand binding pocket at the interface between the dimerization and DNA binding domains.
    3. role of marRAB in susceptibility to cationic antimicrobial peptides
      Title: Different effects of transcriptional regulators MarA, SoxS and Rob on susceptibility of Escherichia coli to cationic antimicrobial peptides (CAMPs): Rob-dependent CAMP induction of the marRAB operon.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor MarR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1619120..1619554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416047.4 DNA-binding transcriptional repressor MarR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416047.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AJW7
      Conserved Domains (1) summary
      PRK11512
      Location:1 → 144
      PRK11512; multiple antibiotic resistance transcriptional regulator MarR
    Nucleotide Protein
    Heading Accession and Version

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