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    msrB methionine sulfoxide reductase B [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947188, updated on 3-Dec-2024

    Summary

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    Official Symbol
    msrB
    Official Full Name
    methionine sulfoxide reductase B
    Primary source
    ECOCYC:EG12394
    Locus tag
    b1778
    See related
    ASAP:ABE-0005916
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1776; yeaA
    Summary
    Tightly binds zinc/iron. [More information is available at EcoGene: EG12394]. MsrB exhibits methionine sulfoxide reductase activity (Km of 6.7 mM) and dimethylsulfoxide reductase activity in vitro . [More information is available at EcoCyc: EG12394].
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    Genomic context

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    Sequence:
    NC_000913.3 (1862016..1862429, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative zinc-binding dehydrogenase YdjL Neighboring gene DUF1315 domain-containing protein YeaC Neighboring gene glyceraldehyde-3-phosphate dehydrogenase A Neighboring gene putative aldose 1-epimerase YeaD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insights into the role of the metal binding site in methionine-R-sulfoxide reductases B. Olry A, et al. Protein Sci, 2005 Nov. PMID 16251365, Free PMC Article
    2. Methionine sulfoxide reductases: history and cellular role in protecting against oxidative damage. Weissbach H, et al. Biochim Biophys Acta, 2005 Jan 17. PMID 15680228
    3. Nucleotide sequence of the Escherichia coli gap gene. Different evolutionary behavior of the NAD+-binding domain and of the catalytic domain of D-glyceraldehyde-3-phosphate dehydrogenase. Branlant G, et al. Eur J Biochem, 1985 Jul 1. PMID 2990926
    4. Repair of oxidized proteins. Identification of a new methionine sulfoxide reductase. Grimaud R, et al. J Biol Chem, 2001 Dec 28. PMID 11677230
    5. The outer membrane localization of the Neisseria gonorrhoeae MsrA/B is involved in survival against reactive oxygen species. Skaar EP, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12096194, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-methionine-(R)-S-oxide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (R)-S-oxide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-methionine (R)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methionine sulfoxide reductase B
    NP_416292.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1862016..1862429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416292.1 methionine sulfoxide reductase B [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416292.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EH69
      Conserved Domains (1) summary
      PRK00222
      Location:1 → 134
      PRK00222; peptide-methionine (R)-S-oxide reductase MsrB
    Nucleotide Protein
    Heading Accession and Version

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