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    flhC DNA-binding transcriptional dual regulator FlhC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947280, updated on 3-Dec-2024

    Summary

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    Official Symbol
    flhC
    Official Full Name
    DNA-binding transcriptional dual regulator FlhC
    Primary source
    ECOCYC:EG10319
    Locus tag
    b1891
    See related
    ASAP:ABE-0006301
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1892; flaI
    Summary
    FlhDC is a transcriptional activator of the flagellar regulon. [More information is available at EcoCyc: EG10319].
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    Genomic context

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    Sequence:
    NC_000913.3 (1977266..1977844, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene chemotaxis protein CheA Neighboring gene motility protein B Neighboring gene motility protein A Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator FlhD Neighboring gene IS1 family protein InsB Neighboring gene IS1 family protein InsA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of cell division, biofilm formation, and virulence by FlhC in Escherichia coli O157:H7 grown on meat. Sule P, et al. Appl Environ Microbiol, 2011 Jun. PMID 21498760, Free PMC Article
    2. Environment-directed activation of the Escherichia coliflhDC operon by transposons. Zhang Z, et al. Microbiology (Reading), 2017 Apr. PMID 28100305, Free PMC Article
    3. Flagellar transcriptional activators FlbB and FlaI: gene sequences and 5' consensus sequences of operons under FlbB and FlaI control. Bartlett DH, et al. J Bacteriol, 1988 Apr. PMID 2832369, Free PMC Article
    4. The C-terminal region of the alpha subunit of Escherichia coli RNA polymerase is required for transcriptional activation of the flagellar level II operons by the FlhD/FlhC complex. Liu X, et al. J Bacteriol, 1995 Sep. PMID 7665504, Free PMC Article
    5. Promoter analysis of the class 2 flagellar operons of Salmonella. Ikebe T, et al. Genes Genet Syst, 1999 Aug. PMID 10650844

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Motility-activating mutations upstream of flhDC reduce acid shock survival of Escherichia coli.
      Title: Motility-activating mutations upstream of flhDC reduce acid shock survival of Escherichia coli.
    2. three IS elements, IS1, IS3 and IS5, transpose to multiple upstream sites within a 370 bp region of the flhDC operon control region. The data are consistent with the possibility that appropriate environmental conditions, namely those that permit but hinder flagellar rotation, result in the activation of a mutational pathway that involves IS element insertion upstream of the flhDC operon.
      Title: Environment-directed activation of the Escherichia coliflhDC operon by transposons.
    3. FlhC is part of flagellar regulatory network.
      Title: Comprehensive mapping of the Escherichia coli flagellar regulatory network.
    4. In conclusion, Hha regulates biofilm formation in enterohemorrhagic Escherichia coli O157:H7 by differential regulation of FlhDC and CsgD, the global regulators of motility and curli production, respectively.
      Title: Hha controls Escherichia coli O157:H7 biofilm formation by differential regulation of global transcriptional regulators FlhDC and CsgD.
    5. Authors report that not only integrations of IS insertion sequences into the regulatory region of the flhDC operon, but also a missense mutation in the lrhA gene enhances motility by relieving transcriptional repression of the flhDC operon.
      Title: Mutations upregulating the flhDC operon of Escherichia coli K-12.
    6. CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage.
      Title: CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage.
    7. Study demonstrates that insertion sequence IS5 in Escherichia coli inserts into the upstream region of the flhDC operon in a manner that depends on whether the environment permits motility.
      Title: IS5 inserts upstream of the master motility operon flhDC in a quasi-Lamarckian way.
    8. Physiological experiments were performed and confirmed that FlhC reduced the cell division rate, the amount of biofilm biomass, and pathogenicity in a chicken embryo lethality model.
      Title: Regulation of cell division, biofilm formation, and virulence by FlhC in Escherichia coli O157:H7 grown on meat.
    9. flhDC mutants of Escherichia coli are nonmotile, better colonize in the intestine, and better utilize sugars than wild type bacteria and Entner-Doudoroff pathway mutants.
      Title: Mouse intestine selects nonmotile flhDC mutants of Escherichia coli MG1655 with increased colonizing ability and better utilization of carbon sources.
    10. crystallographic structure of the Escherichia coli FlhDC complex has been solved to 3.0 A resolution
      Title: Structure of the Escherichia coli FlhDC complex, a prokaryotic heteromeric regulator of transcription.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in bacterial-type flagellum organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of bacterial-type flagellum assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of bacterial-type flagellum assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator FlhC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1977266..1977844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416405.1 DNA-binding transcriptional dual regulator FlhC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416405.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377DR14
      Conserved Domains (1) summary
      PRK12722
      Location:1 → 187
      PRK12722; flagellar transcriptional regulator FlhC
    Nucleotide Protein
    Heading Accession and Version

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