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    tmcA tRNA(Met) cytidine acetyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946053, updated on 3-Dec-2024

    Summary

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    Official Symbol
    tmcA
    Official Full Name
    tRNA(Met) cytidine acetyltransferase
    Primary source
    ECOCYC:G7297
    Locus tag
    b2474
    See related
    ASAP:ABE-0008150
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2470; ypfI
    Summary
    tRNAMet cytidine acetyltransferase acetylates the wobble base C34 of the elongation-specific tRNAMet. [More information is available at EcoCyc: G7297].
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    Genomic context

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    Sequence:
    NC_000913.3 (2593844..2595859, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF13980 family protein YpfN Neighboring gene esterase YpfH Neighboring gene uncharacterized protein YpfJ Neighboring gene phosphoribosylaminoimidazole-succinocarboxamide synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TmcA functions as a lysine 2-hydroxyisobutyryltransferase to regulate transcription. Dong H, et al. Nat Chem Biol, 2022 Feb. PMID 34903851
    2. The role of the minor base N4-acetylcytidine in the function of the Escherichia coli noninitiator methionine transfer RNA. Stern L, et al. J Biol Chem, 1978 Sep 10. PMID 355249
    3. The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon. Ikeuchi Y, et al. EMBO J, 2008 Aug 20. PMID 18668122, Free PMC Article
    4. Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features. Yamamoto Y, et al. DNA Res, 1997 Apr 28. PMID 9205837
    5. RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon. Chimnaronk S, et al. EMBO J, 2009 May 6. PMID 19322199, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, transferring groups other than amino-acyl groups IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide 2-hydroxyisobutyryltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA cytidine N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA acetylation involved in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA acetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble cytosine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble cytosine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble cytosine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA(Met) cytidine acetyltransferase
    NP_416969.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2593844..2595859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416969.1 tRNA(Met) cytidine acetyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416969.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8QTU7
      Conserved Domains (1) summary
      COG1444
      Location:1 → 671
      TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version

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