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    mltB membrane-bound lytic murein transglycosylase B [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947184, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mltB
    Official Full Name
    membrane-bound lytic murein transglycosylase B
    Primary source
    ECOCYC:G7410
    Locus tag
    b2701
    See related
    ASAP:ABE-0008885
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2696; slt
    Summary
    MltB cleaves the glycosidic bonds between the N-acetylmuramic acid and N-acetylglucosamine residues in murein. [More information is available at EcoGene: EG12699]. MltB is one of six (along with MltA, MltC, MltD, EmtA, and Slt70) major lytic endotransglycosylases expressed in Escherichia coli. [More information is available at EcoCyc: G7410].
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    Genomic context

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    Sequence:
    NC_000913.3 (2824491..2825576, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA recombination/repair protein RecA Neighboring gene NMN aminohydrolase Neighboring gene sorbitol-specific PTS enzyme IIC2 component Neighboring gene sorbitol-specific PTS enzyme IIBC1 component Neighboring gene sorbitol-specific PTS enzyme IIA component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lytic transglycosylase MltB of Escherichia coli and its role in recycling of peptidoglycan strands of bacterial cell wall. Suvorov M, et al. J Am Chem Soc, 2008 Sep 10. PMID 18700763, Free PMC Article
    2. Cloning and controlled overexpression of the gene encoding the 35 kDa soluble lytic transglycosylase from Escherichia coli. Dijkstra AJ, et al. FEBS Lett, 1995 Jun 12. PMID 7789526
    3. Accelerated X-ray structure elucidation of a 36 kDa muramidase/transglycosylase using wARP. Van Asselt EJ, et al. Acta Crystallogr D Biol Crystallogr, 1998 Jan 1. PMID 9761817
    4. Crystal structure of Escherichia coli lytic transglycosylase Slt35 reveals a lysozyme-like catalytic domain with an EF-hand. van Asselt EJ, et al. Structure, 1999 Oct 15. PMID 10545329
    5. Binding of calcium in the EF-hand of Escherichia coli lytic transglycosylase Slt35 is important for stability. van Asselt EJ, et al. FEBS Lett, 1999 Sep 24. PMID 10570954

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lytic endotransglycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lytic transglycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lytic transglycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sodium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peptidoglycan catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within peptidoglycan catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer membrane-bounded periplasmic space TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    membrane-bound lytic murein transglycosylase B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2824491..2825576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417181.1 membrane-bound lytic murein transglycosylase B [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417181.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5YCX3
      Conserved Domains (1) summary
      PRK10760
      Location:1 → 361
      PRK10760; murein hydrolase B; Provisional
    Nucleotide Protein
    Heading Accession and Version

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