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    sdhE FAD assembly factor [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947382, updated on 17-Dec-2024

    Summary

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    Official Symbol
    sdhE
    Official Full Name
    FAD assembly factor
    Primary source
    ECOCYC:G7510
    Locus tag
    b2897
    See related
    ASAP:ABE-0009507
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cptB; ECK2892; ygfY
    Summary
    Crystal structures of YgfY have been solved at 1.2 and 2 resolution. [More information is available at EcoCyc: G7510].
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    Genomic context

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    Sequence:
    NC_000913.3 (3040804..3041070, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene site-specific recombinase Neighboring gene flavodoxin 2 Neighboring gene protein YgfX Neighboring gene folate-binding protein Neighboring gene hemolysin-III family protein YqfA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Binding of the Covalent Flavin Assembly Factor to the Flavoprotein Subunit of Complex II. Maklashina E, et al. J Biol Chem, 2016 Feb 5. PMID 26644464, Free PMC Article
    2. Crystal structure of the YgfY from Escherichia coli, a protein that may be involved in transcriptional regulation. Lim K, et al. Proteins, 2005 Feb 15. PMID 15593094
    3. The succinate dehydrogenase assembly factor, SdhE, is required for the flavinylation and activation of fumarate reductase in bacteria. McNeil MB, et al. FEBS Lett, 2014 Jan 31. PMID 24374335
    4. The transcriptional response of Escherichia coli to recombinant protein insolubility. Smith HE. J Struct Funct Genomics, 2007 Mar. PMID 17992580
    5. Progress in understanding structure-function relationships in respiratory chain complex II. Ackrell BA. FEBS Lett, 2000 Jan 21. PMID 10648801

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These studies identify how the conserved SdhE assembly factor and its homologs participate in complex II maturation.
      Title: Binding of the Covalent Flavin Assembly Factor to the Flavoprotein Subunit of Complex II.
    2. SdhE interacted with, and flavinylated, the flavoprotein subunit FrdA, whilst mutations in a conserved RGxxE motif impaired the complete flavinylation and activation of FRD
      Title: The succinate dehydrogenase assembly factor, SdhE, is required for the flavinylation and activation of fumarate reductase in bacteria.
    3. YgfY may be involved in transcriptional regulation, as shown by X-ray crystallographic analysis
      Title: Crystal structure of the YgfY from Escherichia coli, a protein that may be involved in transcriptional regulation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within respiratory chain complex II assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in respiratory chain complex II assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in succinate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within succinate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FAD assembly factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3040804..3041070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417373.1 FAD assembly factor [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417373.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A135PSP2, A0A829LDG4, A0AAN3MCM6
      Conserved Domains (1) summary
      PRK10878
      Location:17 → 88
      PRK10878; FAD assembly factor SdhE
    Nucleotide Protein
    Heading Accession and Version

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