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    nanR NanR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945468, updated on 17-Dec-2024

    Summary

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    Official Symbol
    nanR
    Official Full Name
    NanR
    Primary source
    ECOCYC:G7678
    Locus tag
    b3226
    See related
    ASAP:ABE-0010584
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3215; yhcK
    Summary
    NanR is a GntR-type DNA-binding transcriptional regulator. [More information is available at EcoGene: EG12817]. The genes regulated by NanR, "N-acetyl-neuraminic acid regulator," are involved in N-acetyl-neuraminic acid (or sialic acid) transport and metabolism and in off-to-on switching of type 1 fimbriation. [More information is available at EcoCyc: G7678].
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    Genomic context

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    Sequence:
    NC_000913.3 (3373698..3374489, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene N-acetylneuraminate:H(+) symporter Neighboring gene N-acetylneuraminate lyase Neighboring gene putative transporter DcuD Neighboring gene ClpXP protease specificity-enhancing factor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism. Horne CR, et al. Nat Commun, 2021 Mar 31. PMID 33790291, Free PMC Article
    2. A theoretical interpretation of the transient sialic acid toxicity of a nanR mutant of Escherichia coli. Chu D, et al. J Mol Biol, 2008 Jan 18. PMID 18054045
    3. Genome-wide analysis of deoxyadenosine methyltransferase-mediated control of gene expression in Escherichia coli. Oshima T, et al. Mol Microbiol, 2002 Aug. PMID 12139615
    4. Multiple co-regulatory elements and IHF are necessary for the control of fimB expression in response to sialic acid and N-acetylglucosamine in Escherichia coli K-12. Sohanpal BK, et al. Mol Microbiol, 2007 Feb. PMID 17238917
    5. Integrated regulatory responses of fimB to N-acetylneuraminic (sialic) acid and GlcNAc in Escherichia coli K-12. Sohanpal BK, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15534208, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism.
      Title: Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein-containing complex assembly EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NanR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3373698..3374489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417693.3 NanR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417693.3

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FJY5
      Conserved Domains (1) summary
      PRK03837
      Location:19 → 260
      PRK03837; transcriptional regulator NanR; Provisional
    Nucleotide Protein
    Heading Accession and Version

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