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    argR DNA-binding transcriptional dual regulator ArgR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947861, updated on 3-Dec-2024

    Summary

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    Official Symbol
    argR
    Official Full Name
    DNA-binding transcriptional dual regulator ArgR
    Primary source
    ECOCYC:EG10070
    Locus tag
    b3237
    See related
    ASAP:ABE-0010620
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3226; Rarg; xerA
    Summary
    ArgR is a protein that negatively controls the expression of arginine biosynthesis in addition to the carAB operon. [More information is available at EcoCyc: EG10070].
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    Genomic context

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    Sequence:
    NC_000913.3 (3384703..3385173)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene serine endoprotease Neighboring gene malate dehydrogenase Neighboring gene DUF1471 domain-containing stress-induced protein YhcN Neighboring gene putative barnase inhibitor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of plasmids carrying the arginine repressor gene argR of Escherichia coli K12. Eckhardt T. Mol Gen Genet, 1980. PMID 6993848
    2. Application of the linear interaction energy method (LIE) to estimate the binding free energy values of Escherichia coli wild-type and mutant arginine repressor C-terminal domain (ArgRc)-l-arginine and ArgRc-l-citrulline protein-ligand complexes. Asi AM, et al. J Mol Graph Model, 2004 Mar. PMID 15177077
    3. Arginine control of transcription of argECBH messenger ribonucleic acid in Escherichia coli. Krzyzek R, et al. J Bacteriol, 1972 Jun. PMID 4555419, Free PMC Article
    4. Computational docking of L-arginine and its structural analogues to C-terminal domain of Escherichia coli arginine repressor protein (ArgRc). Kueh R, et al. J Mol Model, 2003 Apr. PMID 12707802
    5. Arginine operator binding by heterologous and chimeric ArgR repressors from Escherichia coli and Bacillus stearothermophilus. Ghochikyan A, et al. J Bacteriol, 2002 Dec. PMID 12426349, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli.
      Title: Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli.
    2. three ArgR-binding modes defined by the position of the two ARG boxes indicate that DNA bends centered between the pair of ARG boxes facilitate the non-specific contacts between ArgR subunits and the residual sequences
      Title: The architecture of ArgR-DNA complexes at the genome-scale in Escherichia coli.
    3. These results show that the C-terminus of ArgR is more important in cer/Xer site-specific recombination than in DNA binding.
      Title: Escherichia coli ArgR mutants defective in cer/Xer recombination, but not in DNA binding.
    4. ArgR-dependent repression of arginine and histidine transport genes in Escherichia coli K-12
      Title: ArgR-dependent repression of arginine and histidine transport genes in Escherichia coli K-12.
    5. N-terminus verified by Edman degradation on complete protein
      Title: Nucleotide sequence of the argR gene of Escherichia coli K-12 and isolation of its product, the arginine repressor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arginine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within plasmid recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein complex oligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of arginine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of arginine catabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator ArgR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3384703..3385173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417704.1 DNA-binding transcriptional dual regulator ArgR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417704.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376LBX8
      Conserved Domains (1) summary
      PRK05066
      Location:1 → 156
      PRK05066; transcriptional regulator ArgR
    Nucleotide Protein
    Heading Accession and Version

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