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    mmuM homocysteine S-methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946143, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mmuM
    Official Full Name
    homocysteine S-methyltransferase
    Primary source
    ECOCYC:G6136
    Locus tag
    b0261
    See related
    ASAP:ABE-0000895
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0263; yagD
    Summary
    Met regulon. [More information is available at EcoGene: EG13343]. MmuM is an S-methylmethionine: homocysteine methyltransferase involved in S-methylmethionine utilization . [More information is available at EcoCyc: G6136].
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    Genomic context

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    Sequence:
    NC_000913.3 (276715..277647)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF00078 domain-containing protein YkfC Neighboring gene IS5 family transposase and trans-activator Neighboring gene S-methyl-L-methionine transporter Neighboring gene ABC transporter ATP-binding protein AfuC Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli. Li K, et al. Biochem J, 2016 Feb 1. PMID 26564203
    2. Selenocysteine methyltransferase. Neuhierl B, et al. Methods Enzymol, 2002. PMID 11898408
    3. Cell division, one-carbon metabolism and methionine synthesis in a metK-deficient Escherichia coli mutant, and a role for MmuM. El-Hajj ZW, et al. Microbiology (Reading), 2013 Oct. PMID 23912937
    4. Over 1000 genes are involved in the DNA damage response of Escherichia coli. Khil PP, et al. Mol Microbiol, 2002 Apr. PMID 11967071
    5. Global analysis of candidate genes important for fitness in a competitive biofilm using DNA-array-based transposon mapping. Junker LM, et al. Microbiology (Reading), 2006 Aug. PMID 16849790

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structures of mmuM reveal a metal/substrate-binding pocket distinct from those in related enzymes.
      Title: Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli.
    2. The metK deficient Escherichia coli mutant uses externally provided S-adenosylmethionine as methyl donor to produce most but not all of its methionine, by methylation of homocysteine catalysed by MmuM.
      Title: Cell division, one-carbon metabolism and methionine synthesis in a metK-deficient Escherichia coli mutant, and a role for MmuM.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables S-adenosylmethionine-homocysteine S-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-adenosylmethionine-homocysteine S-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-adenosylmethionine-homocysteine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-methylmethionine-homocysteine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in S-methylmethionine cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within S-methylmethionine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homocysteine S-methyltransferase
    NP_414795.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      276715..277647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414795.1 homocysteine S-methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414795.1

      Status: PROVISIONAL

      Conserved Domains (1) summary
      PRK09485
      Location:4 → 309
      mmuM; homocysteine methyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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