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    prpD 2-methylcitrate dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945931, updated on 17-Dec-2024

    Summary

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    Official Symbol
    prpD
    Official Full Name
    2-methylcitrate dehydratase
    Primary source
    ECOCYC:G6199
    Locus tag
    b0334
    See related
    ASAP:ABE-0001152
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    acnC; ECK0331; yahT
    Summary
    Crp regulon. [More information is available at EcoGene: EG13603]. The prpD gene encodes 2-methylcitrate dehydratase activity and also encodes the minor aconitase activity, aconitase C , which constitutes 5% or less of cellular activity and is observed in an acnA acnB double mutant . [More information is available at EcoCyc: G6199].
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    Genomic context

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    Sequence:
    NC_000913.3 (351215..352666)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2-methylisocitrate lyase Neighboring gene 2-methylcitrate synthase Neighboring gene propionyl-CoA synthetase Neighboring gene cytosine transporter Neighboring gene cytosine/isoguanine deaminase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Construction and properties of aconitase mutants of Escherichia coli. Gruer MJ, et al. Microbiology (Reading), 1997 Jun. PMID 9202458
    2. Propionate catabolism in Salmonella typhimurium LT2: two divergently transcribed units comprise the prp locus at 8.5 centisomes, prpR encodes a member of the sigma-54 family of activators, and the prpBCDE genes constitute an operon. Horswill AR, et al. J Bacteriol, 1997 Feb. PMID 9006051, Free PMC Article
    3. Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle. Horswill AR, et al. J Bacteriol, 1999 Sep. PMID 10482501, Free PMC Article
    4. Propionate oxidation in Escherichia coli: evidence for operation of a methylcitrate cycle in bacteria. Textor S, et al. Arch Microbiol, 1997 Nov. PMID 9325432
    5. Temporal gene-expression in Escherichia coli K-12 biofilms. Domka J, et al. Environ Microbiol, 2007 Feb. PMID 17222132

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-methylcitrate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-methylcitrate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aconitate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within propionate metabolic process, methylcitrate cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in propionate metabolic process, methylcitrate cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2-methylcitrate dehydratase
    NP_414868.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      351215..352666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414868.1 2-methylcitrate dehydratase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414868.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7XFU9, A0AAD2ZCA6
      Conserved Domains (1) summary
      PRK09425
      Location:1 → 483
      prpD; bifunctional 2-methylcitrate dehydratase/aconitate hydratase
    Nucleotide Protein
    Heading Accession and Version

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