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    yajO 1-deoxyxylulose-5-phosphate synthase YajO [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946903, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yajO
    Official Full Name
    1-deoxyxylulose-5-phosphate synthase YajO
    Primary source
    ECOCYC:G6236
    Locus tag
    b0419
    See related
    ASAP:ABE-0001457
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0413
    Summary
    YajO converts 2-carboxybenzaldehyde, like other AKR7A family enzymes, however specificities toward other substrates was not demonstrated. [More information is available at EcoGene: EG13611]. Overexpression of YajO from a multicopy plasmid leads to resistance to the HMP (4-amino-2-methyl-5-hydroxymethylpyrimidine) analog bacimethrin. [More information is available at EcoCyc: G6236].
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    Genomic context

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    Sequence:
    NC_000913.3 (437161..438135, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene transcription antitermination protein NusB Neighboring gene thiamine monophosphate kinase Neighboring gene phosphatidylglycerophosphatase A Neighboring gene 1-deoxy-D-xylulose-5-phosphate synthase Neighboring gene geranyl diphosphate/farnesyl diphosphate synthase Neighboring gene exodeoxyribonuclease VII subunit XseB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and nucleotide sequence of the ispA gene responsible for farnesyl diphosphate synthase activity in Escherichia coli. Fujisaki S, et al. J Biochem, 1990 Dec. PMID 2089044
    2. Isolation and preliminary characterization of Escherichia coli mutants deficient in exonuclease VII. Vales LD, et al. J Bacteriol, 1983 Sep. PMID 6350262, Free PMC Article
    3. Conversion of methylglyoxal to acetol by Escherichia coli aldo-keto reductases. Ko J, et al. J Bacteriol, 2005 Aug. PMID 16077126, Free PMC Article
    4. Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli. Kerner MJ, et al. Cell, 2005 Jul 29. PMID 16051146
    5. A genetic screen for the identification of thiamin metabolic genes. Lawhorn BG, et al. J Biol Chem, 2004 Oct 15. PMID 15292217

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within isoprenoid biosynthetic process via mevalonate EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within thiamine metabolic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-deoxyxylulose-5-phosphate synthase YajO

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      437161..438135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414953.2 1-deoxyxylulose-5-phosphate synthase YajO [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414953.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9WYK3, A0AAE9Q7H0
      Conserved Domains (1) summary
      cd19079
      Location:2 → 312
      AKR_EcYajO-like; Escherichia coli YajO and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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