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    kdpD sensor histidine kinase KdpD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946744, updated on 3-Dec-2024

    Summary

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    Official Symbol
    kdpD
    Official Full Name
    sensor histidine kinase KdpD
    Primary source
    ECOCYC:EG10516
    Locus tag
    b0695
    See related
    ASAP:ABE-0002368
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0683; kac
    Summary
    Inhibition of KdpD phosphatase activity leads to an accumulation of phospho-KdpE and activation of kdpFABC transcription. [More information is available at EcoGene: EG10516]. KdpD is the sensor member of the |FRAME: [More information is available at EcoCyc: EG10516].
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    Genomic context

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    Sequence:
    NC_000913.3 (721730..724414, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putrescine transporter PotE Neighboring gene inducible ornithine decarboxylase Neighboring gene leader peptide SpeFL Neighboring gene DNA-binding transcriptional activator KdpE Neighboring gene K(+) transporting P-type ATPase subunit KdpC Neighboring gene K(+) transporting P-type ATPase subunit KdpB Neighboring gene K(+) transporting P-type ATPase subunit KdpA Neighboring gene K(+) transporting P-type ATPase subunit KdpF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The transmembrane domains of the sensor kinase KdpD of Escherichia coli are not essential for sensing K+ limitation. Heermann R, et al. Mol Microbiol, 2003 Feb. PMID 12535080
    2. Effect of cysteine replacements on the properties of the turgor sensor KdpD of Escherichia coli. Jung K, et al. Biochim Biophys Acta, 1998 Jul 17. PMID 9675324
    3. The cytoplasmic C-terminal domain of the Escherichia coli KdpD protein functions as a K+ sensor. Rothenbücher MC, et al. J Bacteriol, 2006 Mar. PMID 16484207, Free PMC Article
    4. Chromosomal Location of a Gene Involved in Potassium Ion Uptake in Escherichia coli B. Burmeister M. J Bacteriol, 1969 Nov. PMID 16559072, Free PMC Article
    5. Characterization of truncated forms of the KdpD protein, the sensor kinase of the K+-translocating Kdp system of Escherichia coli. Puppe W, et al. J Biol Chem, 1996 Oct 4. PMID 8798785

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural insights into the signal transduction mechanism of the K(+)-sensing two-component system KdpDE.
      Title: Structural insights into the signal transduction mechanism of the K(+)-sensing two-component system KdpDE.
    2. Structure and function of the juxtamembrane GAF domain of potassium biosensor KdpD.
      Title: Structure and function of the juxtamembrane GAF domain of potassium biosensor KdpD.
    3. The SRP signal sequence of KdpD.
      Title: The SRP signal sequence of KdpD.
    4. In this report authors provide evidence that the extracellular K(+) concentration serves as one of the stimuli sensed by KdpD.
      Title: The sensor kinase KdpD of Escherichia coli senses external K+.
    5. The ArcB and QseC transmembrane (TM) domains are both two-helical motifs, whereas the KdpD TM domain comprises a four-helical bundle with shorter second and third helices. The interhelical distances reveal weak interactions of all three receptors.
      Title: Membrane domain structures of three classes of histidine kinase receptors by cell-free expression and rapid NMR analysis.
    6. The response regulator KdpE receives the phosphoryl group from KdpD and induces kdpFABC transcription.
      Title: The complexity of the 'simple' two-component system KdpD/KdpE in Escherichia coli.
    7. Data show that kinase activity of KdpD is stimulated in its native membrane environment by fusion with liposomes of anionic, but reduced with liposomes of zwitterionic phospholipids.
      Title: Influence of K+-dependent membrane lipid composition on the expression of the kdpFABC operon in Escherichia coli.
    8. The Usp domain within KdpD is important for proper KdpD/KdpE signaling.
      Title: Domain swapping reveals that the N-terminal domain of the sensor kinase KdpD in Escherichia coli is important for signaling.
    9. Dephosphorylated IIANtr enhances activity of the kdp promoter by direct binding of dephosphorylated IIA(Ntr) to the sensor kinase KdpD.
      Title: Stimulation of the potassium sensor KdpD kinase activity by interaction with the phosphotransferase protein IIA(Ntr) in Escherichia coli.
    10. The universal stress protein UspC scaffolds the KdpD/KdpE signaling cascade of Escherichia coli under salt stress
      Title: The universal stress protein UspC scaffolds the KdpD/KdpE signaling cascade of Escherichia coli under salt stress.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay sensor kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorelay sensor kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity, transferring phosphorus-containing groups IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to potassium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sensor histidine kinase KdpD
    NP_415223.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      721730..724414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415223.1 sensor histidine kinase KdpD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415223.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1QH27, A0A8T6A2K8
      Conserved Domains (1) summary
      PRK10490
      Location:1 → 894
      PRK10490; sensor protein KdpD; Provisional
    Nucleotide Protein
    Heading Accession and Version

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