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    puuR DNA-binding transcriptional repressor PuuR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945886, updated on 3-Dec-2024

    Summary

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    Official Symbol
    puuR
    Official Full Name
    DNA-binding transcriptional repressor PuuR
    Primary source
    ECOCYC:EG12431
    Locus tag
    b1299
    See related
    ASAP:ABE-0004371
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1294; ycjC
    Summary
    PuuR may be a transcriptional regulator of genes encoding enzymes in a putrescine degradation pathway . [More information is available at EcoCyc: EG12431].
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    Genomic context

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    Sequence:
    NC_000913.3 (1361911..1362468)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glutamate-putrescine ligase Neighboring gene gamma-glutamyl-gamma-aminobutyrate hydrolase Neighboring gene gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase Neighboring gene gamma-glutamylputrescine oxidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism for regulation of the putrescine utilization pathway by the transcription factor PuuR in Escherichia coli K-12. Nemoto N, et al. J Bacteriol, 2012 Jul. PMID 22522900, Free PMC Article
    2. A putrescine-inducible pathway comprising PuuE-YneI in which gamma-aminobutyrate is degraded into succinate in Escherichia coli K-12. Kurihara S, et al. J Bacteriol, 2010 Sep. PMID 20639325, Free PMC Article
    3. Cloning an Escherichia coli gene encoding a protein remarkably similar to mammalian aldehyde dehydrogenases. Heim R, et al. Gene, 1991 Mar 1. PMID 1840553
    4. gamma-Glutamylputrescine synthetase in the putrescine utilization pathway of Escherichia coli K-12. Kurihara S, et al. J Biol Chem, 2008 Jul 18. PMID 18495664
    5. A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12. Kurihara S, et al. J Biol Chem, 2005 Feb 11. PMID 15590624

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that PuuR regulates the intracellular putrescine concentration by the transcriptional regulation of genes in the Puu pathway, including puuR itself.
      Title: Mechanism for regulation of the putrescine utilization pathway by the transcription factor PuuR in Escherichia coli K-12.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in putrescine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor PuuR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1361911..1362468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415815.1 DNA-binding transcriptional repressor PuuR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415815.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      W1EZY4
      Conserved Domains (1) summary
      PRK09943
      Location:1 → 185
      PRK09943; HTH-type transcriptional regulator PuuR
    Nucleotide Protein
    Heading Accession and Version

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