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    ogt methylated-DNA--[protein]-cysteine S-methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945853, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ogt
    Official Full Name
    methylated-DNA--[protein]-cysteine S-methyltransferase
    Primary source
    ECOCYC:EG10668
    Locus tag
    b1335
    See related
    ASAP:ABE-0004486
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1331
    Summary
    Ogt is the second (after Ada) methyltransferase enzyme for the direct repair of alkylating lesions in Escherichia coli and is responsible the background constitutive alkyl-transfer when the Ada response is not induced. [More information is available at EcoCyc: EG10668].
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    Genomic context

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    Sequence:
    NC_000913.3 (1399721..1400236, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene universal stress protein E Neighboring gene DNA-binding transcriptional dual regulator FNR Neighboring gene p-aminobenzoyl glutamate:H(+) symporter Neighboring gene p-aminobenzoyl-glutamate hydrolase subunit B Neighboring gene p-aminobenzoyl-glutamate hydrolase subunit A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanisms of action of methyl methanesulfonate on Escherichia coli: mutagenesis, DNA damage and repair. Janion C. Postepy Biochem, 1995. PMID 8797228
    2. Site directed mutagenesis of two cysteine residues in the E. coli ogt O6-alkylguanine DNA alkyltransferase protein. Harris LC, et al. Biochem Biophys Res Commun, 1992 Aug 31. PMID 1520330
    3. The suicidal DNA repair methyltransferases of microbes. Samson L. Mol Microbiol, 1992 Apr. PMID 1602962
    4. Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase. Rebeck GW, et al. J Bacteriol, 1991 Mar. PMID 2002008, Free PMC Article
    5. The E. coli ogt gene. Margison GP, et al. Mutat Res, 1990 Nov-Dec. PMID 2233796

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activation by NarL at the Escherichia coli ogt promoter.
      Title: Activation by NarL at the Escherichia coli ogt promoter.
    2. DNase I footprinting studies identified Fis-binding sites that overlap the yeaR promoter NarL site at position -43.5, and the ogt promoter NarL site at position -78.5, and suggest that Fis represses both promoters by displacing NarL.
      Title: Competition between NarL-dependent activation and Fis-dependent repression controls expression from the Escherichia coli yeaR and ogt promoters.
    3. N-terminus verified by Edman degradation on complete protein
      Title: Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA alkylation repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA alkylation repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA alkylation repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    methylated-DNA--[protein]-cysteine S-methyltransferase
    NP_415851.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1399721..1400236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415851.1 methylated-DNA--[protein]-cysteine S-methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415851.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376WYY4
      Conserved Domains (1) summary
      PRK10286
      Location:1 → 171
      PRK10286; methylated-DNA--[protein]-cysteine S-methyltransferase
    Nucleotide Protein
    Heading Accession and Version

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