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    psuK putative pseudouridine kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946664, updated on 3-Dec-2024

    Summary

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    Official Symbol
    psuK
    Official Full Name
    putative pseudouridine kinase
    Primary source
    ECOCYC:EG11646
    Locus tag
    b2166
    See related
    ASAP:ABE-0007168
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2159; pscK; yeiC
    Summary
    PsuK was characterized as the pseudouridine kinase required for pseudouridine utilization in Escherichia coli UT189 (Preumont, 2008; Solomon, 1971). [More information is available at EcoGene: EG11646]. YeiC from the uropathogenic Escherichia coli UTI89 is a pseudouridine kinase; yeiC is the most highly induced gene when UTI89 is grown on human urine . [More information is available at EcoCyc: EG11646].
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    Genomic context

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    Sequence:
    NC_000913.3 (2258355..2259296, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator YeiL Neighboring gene putative pseudouridine transporter Neighboring gene pseudouridine-5'-phosphate glycosidase Neighboring gene fructose-specific PTS multiphosphoryl transfer protein FruA Neighboring gene 1-phosphofructokinase Neighboring gene fructose-specific PTS multiphosphoryl transfer protein FruB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Substrate-binding loop interactions with pseudouridine trigger conformational changes that promote catalytic efficiency of pseudouridine kinase PUKI. Kim SH, et al. J Biol Chem, 2022 May. PMID 35346685, Free PMC Article
    2. Pseudouridine kinase of escherichia coli: a new enzyme. Solomon LR, et al. Biochem Biophys Res Commun, 1971 Jul 16. PMID 4334133
    3. Pseudouridulate synthetase of Escherichia coli: correlation of its activity with utilization of pseudouridine for growth. Breitman TR. J Bacteriol, 1970 Jul. PMID 4912525, Free PMC Article
    4. Growth of pyrimidineless strains of Escherichia coli on 5-ribosyluracil (pseudouridine). Breitman TR, et al. J Bacteriol, 1968 Nov. PMID 4882030, Free PMC Article
    5. The biosynthesis of pseudouridine in ribonucleic acids of Escherichia coli. Ginsberg T, et al. J Biol Chem, 1968 Dec 10. PMID 4881361

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Substrate-binding loop interactions with pseudouridine trigger conformational changes that promote catalytic efficiency of pseudouridine kinase PUKI.
      Title: Substrate-binding loop interactions with pseudouridine trigger conformational changes that promote catalytic efficiency of pseudouridine kinase PUKI.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pseudouridine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pseudouridine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative pseudouridine kinase
    NP_416671.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2258355..2259296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416671.1 putative pseudouridine kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416671.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GKT3, A0A3R0MTC6, A0A8S7F7W3, A0A8S7X704
      Conserved Domains (1) summary
      PRK09850
      Location:1 → 313
      PRK09850; pseudouridine kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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