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    nuoA NADH:quinone oxidoreductase subunit A [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946764, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nuoA
    Official Full Name
    NADH:quinone oxidoreductase subunit A
    Primary source
    ECOCYC:EG12082
    Locus tag
    b2288
    See related
    ASAP:ABE-0007553
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2282
    Summary
    NuoA is part of the inner membrane component of NADH dehydrogenase I . [More information is available at EcoCyc: EG12082].
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    Genomic context

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    Sequence:
    NC_000913.3 (2404629..2405072, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene NADH:quinone oxidoreductase subunit CD Neighboring gene NADH:quinone oxidoreductase subunit B Neighboring gene DNA-binding transcriptional dual regulator LrhA Neighboring gene glutamate--pyruvate aminotransferase AlaA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Revised transmembrane orientation of the NADH:quinone oxidoreductase subunit NuoA. Virzintiene E, et al. FEBS Lett, 2011 Oct 20. PMID 21925501
    2. Monitoring redox-dependent contribution of lipids in Fourier transform infrared difference spectra of complex I from Escherichia coli. Hielscher R, et al. Biopolymers, 2006 Jul. PMID 16358245
    3. Functional roles of four conserved charged residues in the membrane domain subunit NuoA of the proton-translocating NADH-quinone oxidoreductase from Escherichia coli. Kao MC, et al. J Biol Chem, 2004 Jul 30. PMID 15175326
    4. A role for native lipids in the stabilization and two-dimensional crystallization of the Escherichia coli NADH-ubiquinone oxidoreductase (complex I). Sazanov LA, et al. J Biol Chem, 2003 May 23. PMID 12637579
    5. Multiple site-specific binding of Fis protein to Escherichia coli nuoA-N promoter DNA and its impact on DNA topology visualised by means of scanning force microscopy. Zhang J, et al. Chembiochem, 2004 Sep 6. PMID 15368583

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    contributes_to NADH dehydrogenase (ubiquinone) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADH dehydrogenase (ubiquinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to NADH dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADH:ubiquinone reductase (non-electrogenic) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in respiratory electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NADH dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of respiratory chain complex I NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADH:quinone oxidoreductase subunit A
    NP_416791.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2404629..2405072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416791.3 NADH:quinone oxidoreductase subunit A [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416791.3

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376X095, A0A8S7JM68
      Conserved Domains (1) summary
      PRK06602
      Location:6 → 126
      PRK06602; NADH:ubiquinone oxidoreductase subunit A; Validated
    Nucleotide Protein
    Heading Accession and Version

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