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    epmC EF-P-Lys34 hydroxylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946807, updated on 17-Dec-2024

    Summary

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    Official Symbol
    epmC
    Official Full Name
    EF-P-Lys34 hydroxylase
    Primary source
    ECOCYC:G7201
    Locus tag
    b2326
    See related
    ASAP:ABE-0007686
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2320; yfcM
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    Genomic context

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    Sequence:
    NC_000913.3 (2444203..2444751, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene fused tRNA 5-aminomethyl-2-thiouridylate methyltransferase and tRNA 5-aminomethyl-2-thiouridylate synthase Neighboring gene PF08891 family protein YfcL Neighboring gene putative transporter YfcA Neighboring gene peptidoglycan DD-endopeptidase/peptidoglycan LD-endopeptidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The non-canonical hydroxylase structure of YfcM reveals a metal ion-coordination motif required for EF-P hydroxylation. Kobayashi K, et al. Nucleic Acids Res, 2014 Oct 29. PMID 25274739, Free PMC Article
    2. Lys34 of translation elongation factor EF-P is hydroxylated by YfcM. Peil L, et al. Nat Chem Biol, 2012 Aug. PMID 22706199
    3. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article
    4. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article
    5. The complete genome sequence of Escherichia coli K-12. Blattner FR, et al. Science, 1997 Sep 5. PMID 9278503

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data indicate that YfcM is the final enzyme in the EF-P modification pathway
      Title: Lys34 of translation elongation factor EF-P is hydroxylated by YfcM.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables metal ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in post-translational protein modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    EF-P-Lys34 hydroxylase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2444203..2444751 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416829.1 EF-P-Lys34 hydroxylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416829.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7E9D1
      Conserved Domains (1) summary
      COG3101
      Location:1 → 182
      EpmC; Elongation factor P hydroxylase (EF-P beta-lysylation pathway) [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version

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