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    pabA aminodeoxychorismate synthase subunit 2 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947873, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pabA
    Official Full Name
    aminodeoxychorismate synthase subunit 2
    Primary source
    ECOCYC:EG10682
    Locus tag
    b3360
    See related
    ASAP:ABE-0010983
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3348
    Summary
    Component II provides the glutamine amidotransferase activity. [More information is available at EcoCyc: EG10682].
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    Genomic context

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    Sequence:
    NC_000913.3 (3490266..3490829, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YhfK Neighboring gene N-acetylornithine aminotransferase/N-succinyldiaminopimelate aminotransferase Neighboring gene protein YrfJ Neighboring gene putative adenosine monophosphate--protein transferase Fic Neighboring gene DUF2559 domain-containing protein YhfG Neighboring gene peptidyl-prolyl cis-trans isomerase A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis of 4-aminobenzoate in Escherichia coli. Huang M, et al. J Bacteriol, 1970 Jun. PMID 4914080, Free PMC Article
    2. Nucleotide sequence of Escherichia coli pabA and its evolutionary relationship to trp(G)D. Kaplan JB, et al. J Mol Biol, 1983 Aug 15. PMID 6350604
    3. p-aminobenzoate synthesis in Escherichia coli: kinetic and mechanistic characterization of the amidotransferase PabA. Roux B, et al. Biochemistry, 1992 Aug 4. PMID 1637823
    4. Chorismate aminations: partial purification of Escherichia coli PABA synthase and mechanistic comparison with anthranilate synthase. Walsh CT, et al. Biochemistry, 1987 Jul 28. PMID 3311153
    5. Escherichia coli aminodeoxychorismate synthase: analysis of pabB mutations affecting catalysis and subunit association. Rayl EA, et al. Biochim Biophys Acta, 1996 Jun 7. PMID 8679677

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4-amino-4-deoxychorismate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-amino-4-deoxychorismate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4-amino-4-deoxychorismate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to anthranilate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in folic acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in folic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within para-aminobenzoic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tetrahydrofolate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tetrahydrofolate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tryptophan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of aminodeoxychorismate synthase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of aminodeoxychorismate synthase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aminodeoxychorismate synthase subunit 2
    NP_417819.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3490266..3490829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417819.1 aminodeoxychorismate synthase subunit 2 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417819.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A444R1R4
      Conserved Domains (1) summary
      PRK08007
      Location:1 → 187
      PRK08007; aminodeoxychorismate synthase component 2
    Nucleotide Protein
    Heading Accession and Version

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