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    rpoZ RNA polymerase subunit omega [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948160, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rpoZ
    Official Full Name
    RNA polymerase subunit omega
    Primary source
    ECOCYC:EG10899
    Locus tag
    b3649
    See related
    ASAP:ABE-0011933
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3639; spoS
    Summary
    Stimulates ppGpp responsiveness of RNAP in vitro. [More information is available at EcoGene: EG10899]. RpoZ copurifies with RNA polymerase and may play a structural role in that complex. [More information is available at EcoCyc: EG10899].
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    Genomic context

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    Sequence:
    NC_000913.3 (3822106..3822381)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF03458 family inner membrane protein YicG Neighboring gene DNA ligase B Neighboring gene guanylate kinase Neighboring gene bifunctional (p)ppGpp synthase/hydrolase SpoT Neighboring gene tRNA (Gm18) 2'-O-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A noncycling activity assay for the omega subunit of Escherichia coli RNA polymerase. Hansen UM, et al. J Biol Chem, 1979 Jul 10. PMID 376516
    2. Inter-subunit recognition and manifestation of segmental mobility in Escherichia coli RNA polymerase: a case study with omega-beta' interaction. Ghosh P, et al. Biophys Chem, 2003 Mar 25. PMID 12727285
    3. Conversion of the omega subunit of Escherichia coli RNA polymerase into a transcriptional activator or an activation target. Dove SL, et al. Genes Dev, 1998 Mar 1. PMID 9499408, Free PMC Article
    4. Studies on the omega subunit of Escherichia coli RNA polymerase--its role in the recovery of denatured enzyme activity. Mukherjee K, et al. Eur J Biochem, 1997 Aug 1. PMID 9288911
    5. Cross-linking of Escherichia coli RNA polymerase subunits: identification of beta' as the binding site of omega. Gentry DR, et al. Biochemistry, 1993 Oct 19. PMID 8218187

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study identified a new phenotype of rpoZ strain corresponding to defect in biofilm formation in minimal media.
      Title: The role of ω-subunit of Escherichia coli RNA polymerase in stress response.
    2. The results indicate that polyamine stimulation of synthesis of SpoT and RpoZ plays important roles for cell viability through stimulation of ppGpp synthesis by SpoT and modulation of RNA synthesis by ppGpp-RpoZ complex.
      Title: Increase in cell viability by polyamines through stimulation of the synthesis of ppGpp regulatory protein and ω protein of RNA polymerase in Escherichia coli.
    3. Deletion of rpoZ alters the sigma factor selectivity of promoter recognition.
      Title: Structural coupling between RNA polymerase composition and DNA supercoiling in coordinating transcription: a global role for the omega subunit?
    4. N-terminus verified by Edman degradation on mature peptide
      Title: Small genes/gene-products in Escherichia coli K-12.
    5. the omega subunit of RNA polymerase is involved in regulation of the relA gene
      Title: The role of the omega subunit of RNA polymerase in expression of the relA gene in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase I activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase III activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase IV activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase V activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables bacterial-type RNA polymerase core enzyme binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables plastid single subunit type RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated transcription initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA-templated transcription initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in bacterial-type flagellum assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in bacterial-type flagellum-dependent cell motility NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell motility NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to cell envelope stress NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in nitrate assimilation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in plastid transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription elongation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to heat NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in submerged biofilm formation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription antitermination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase IV IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase V IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic DNA-directed RNA polymerase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytosolic DNA-directed RNA polymerase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase subunit omega

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3822106..3822381
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418106.1 RNA polymerase subunit omega [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418106.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AXC3
      Conserved Domains (1) summary
      TIGR00690
      Location:1 → 60
      rpoZ; DNA-directed RNA polymerase, omega subunit
    Nucleotide Protein
    Heading Accession and Version

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